Extensive Handling of Rats Leads to Mild Urinary Bladder Hyperplasia

Toxicologic Pathology

Volumn 24, Issue 2, 1996, Pages 251-257

  Cohen, Samuel M ^a   Cano, Martin ^a   Anderson, Traci ^a   Garland, Emily M ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

regeneration; saccharin; Stress; toxicity; urine; urothelium

Indexed keywords

SACCHARIN SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER DISEASE; CONTROLLED STUDY; HYPERPLASIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; STRESS; TISSUE NECROSIS; URINALYSIS; UROTHELIUM;

ANIMALS; BODY WEIGHT; CARCINOGENS; DRINKING; EPITHELIUM; HANDLING (PSYCHOLOGY); HYPERPLASIA; MALE; MICROSCOPY, ELECTRON, SCANNING; NECROSIS; RATS; RATS, INBRED F344; SACCHARIN; URINARY BLADDER;

ANIMALIA;

EID: 0029913033     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339602400214     Document Type: Article

References (9)

1. Cohen SM (1995). The role of urine physiology and chemistry in bladder carcinogenesis. Food Chem. Toxicol. 33: 715-730.
2. Cohen SM, Cano M., Garland EM, St John M., and Arnold LL (1995). Urinary and urothelial effects of sodium salts in male rats. Carcinogenesis 16: 343-348.
3. Cohen SM, Fisher MJ, Sakata T., Cano M., Schoenig GP, Chappel CI, and Garland EM (1990). Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography. Scanning Microsc. 4: 135-142.
4. Dalal E., Medalia O., Harari O., and Aronson M. (1994). Moderate stress protects female mice against bacterial infection of the bladder by eliciting uroepithelial shedding. Infect. Immun. 62: 5505-5510.
5. Ellwein LB and Cohen SM (1990). The health risks of saccharin revisited. Crit. Rev. Toxicol. 20: 311-326.
6. Fisher MJ, Sakata T., Tibbels TS, Smith RA, Patil K., Khachab M., Johansson SL, and Cohen SM (1989). Effect of sodium saccharin and calcium saccharin on urinary parameters in rats fed Prolab 3200 or AIN-76 diet. Food Chem. Toxicol. 27: 1-9.
7. Martin RA, Daly AM, Difonzo CJ, and de la Iglesia FA (1984). Randomization of animals by computer program for toxicity studies. J. Am. Coll. Toxicol. 3: 1-11.
8. SAS Institute (1989). SAS/STAT User's Guide Statistics, Vol. II, version 6, 4th ed. SAS Institute Inc., Cary, North Carolina.
9. Tibbels TS, Smith RA, and Cohen SM (1988). Determination of saccharin in diet and biological materials. J. Chromatogr. 441: 448-453.