Valproic acid has temporal variability in urinary clearance of metabolites

Chronobiology International

Volumn 18, Issue 1, 2001, Pages 123-129

  Reith, D M ^a   Andrews, J ^a   McLaughlin, D ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Clearance; Day night; Metabolism; Renal; Valproate

Indexed keywords

3 OXOVALPROIC ACID; 4 HYDROXYVALPROIC ACID; CREATININE; DRUG METABOLITE; GLUCURONIDE; UNCLASSIFIED DRUG; VALPROIC ACID;

ADULT; ARTICLE; CIRCADIAN RHYTHM; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; KIDNEY CLEARANCE; MALE; NORMAL HUMAN; STEADY STATE;

ADOLESCENT; ADULT; ANTICONVULSANTS; CIRCADIAN RHYTHM; HUMANS; MALE; VALPROIC ACID;

EID: 0035124082     PISSN: 07420528     EISSN: None     Source Type: Journal    
DOI: 10.1081/CBI-100001176     Document Type: Article

References (19)

1. Urinary excretion of valproate and some metabolites in chronically treated patients
2. Effect of felbamate on valproic acid disposition in healthy volunteers: Inhibition of b-Oxidation
3. Serum Creatinine Determination without Protein Precipitation
4. Aspects of the dose-dependent metabolism of valproic acid
5. Chronopharmacokinetic study of valproic acid in man: Comparison of oral and rectal administration
6. Time-dependent kinetics III: Diurnal oscillations in steady-state plasma valproic acid levels in rhesus monkeys
7. Diurnal variation of valproic acid plasma levels and day-night reversal in monkey
8. Chronopharmacokinetics of valproic acid following constant-rate administration in mice
9. Influence of food intake on the pharmacokinetics of a sustained release formulation of sodium valproate
10. Influence of feeding schedule on the chronopharmacological aspects of sodium valproate in mice
11. Circadian rhythm of embryotoxicity induced by sodium valproale in mice
12. Chronotoxicity of sodium valproate and its mechanisms in mice
13. Valproic acid clearance: Unbound fraction and diurnal variation in young and elderly adults
14. Normal creatinine and hydroxyproline excretion in young persons
15. Creatinine excretion over 24 hours as a measure of body composition or of completeness of urine collection
16. Urinary creatinine excretion as an index of the completeness of 24-hour urine collections
17. Chronopharmacology of methotrexate pharmacokinetics in childhood leukaemia