Effect of felbamate on valproic acid disposition in healthy volunteers: Inhibition of β-oxidation

Epilepsia

Volumn 37, Issue 1, 1996, Pages 91-97

  Hooper, W D ^a,c   Franklin, M E ^a   Glue, P ^b   Banfield, C R ^b   Radwanski, E ^b   McLaughlin, D B ^a   McIntyre, M E ^a   Dickinson, R G ^a   Eadie, M J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MERCK RESEARCH LABORATORIES   (United States)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

Oxidation; Drug interactions; Felbamate; Valproate

Indexed keywords

DRUG METABOLITE; FELBAMATE; GLUCURONIDE; VALPROIC ACID;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG URINE LEVEL; FATTY ACID OXIDATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; NEUROTOXICITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANTICONVULSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; HUMANS; MALE; METABOLIC CLEARANCE RATE; OXIDATION-REDUCTION; PLACEBOS; PROPYLENE GLYCOLS; VALPROIC ACID;

EID: 0030048917     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.1996.tb00518.x     Document Type: Article

References (18)

1. Palmer KJ, McTavish D. Felbamate: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in epilepsy. Drugs 1993;45:1041-65.
2. Dodson WE. Felbamate in the treatment of Lennox-Gastaut syndrome: results of a 12-month open-label study following a randomized clinical trial. Epilepsia 1993;34(suppl 7):S18-24.
3. Jensen PK. Felbamate in the treatment of refractory partial-onset seizures. Epilepsia 1993;34(suppl 7):S25-9.
4. Wagner ML. Felbamate: a new antiepileptic drug. Am J Hosp Pharm 1994;51:1657-66.
5. Sachdeo R, Wagner M, Sachdeo S, et al. Steady-state pharmacokinetics of phenytoin when coadministered with felbamate (Felbatol). Epilepsia 1992;33(suppl 3):84.
6. Albani F, Theodore WH, Washington P, et al. Effect of felbamate on plasma levels of carbamazepine and its metabolites. Epilepsia 1991;32:130-2.
7. Wagner ML, Remmel RP, Graves NM, et al. Effect of felbamate on carbamazepine and its major metabolites. Clin Pharmacol Ther 1993;53:536-43.
8. Wagner ML, Graves NM, Leppik IE, et al. The effect of felbamate on valproate disposition. Epilepsia 1991;32(suppl 3):15.
9. Wagner ML, Graves NM, Leppik IE, et al. The effect of felbamate on valproic acid disposition. Clin Pharmacol Ther 1994;56:494-502.
10. Dickinson RG, Harland RC, Ilias AM, et al. Disposition of valproic acid in the rat: dose-dependent metabolism, distribution, enterohepatic recirculation and choleretic effect. J Pharmacol Exp Ther 1979;211:583-95.
11. Gibaldi M, Perrier D. Pharmacokinetics, 2nd ed. New York: Marcel Dekker, 1982:409-17.
12. Ward DL, Wagner ML, Perhach JL, et al. Felbamate steady-state pharmacokinetics during coadministration of valproate. Epilepsia 1991;32(suppl 3):8.
13. Dickinson RG, Hooper WD, Dunstan PR, Eadie MJ. Urinary excretion of valproate and some metabolites in chronically treated patients. Ther Drug Monit 1989;11:127-33.
14. Granneman GR, Marriott TB, Wang SI, et al. Aspects of the dose-dependent metabolism of valproic acid. In: Levy RH, Pitlick WH, Eichelbaum M, Meijer J, eds. Metabolism of antiepileptic drugs. New York: Raven Press, 1984:97-104.
15. Bernus I, Dickinson RG, Hooper WD, Franklin ME, Eadie MJ. The effect of felbamate on the plasma protein binding of valproate. (Submitted for publication)
16. Ward DL, Weliky I, Schumaker RC, Perhach JL. Dose proportionality of felbamate (Fetbatol) following oral administration of 200, 400 or 600 mg bid to healthy men [Abstract]. Epilepsia 1992;33(suppl 3):83-4.
17. Banfield CR, Zhu GR, Jen FJ, et al. The effect of age on the apparent clearance of felbamate: a retrospective analysis using non-linear mixed effects modelling. Ther Drug Monit (in press).
18. 14C]felbamate in healthy men [Abstract]. Epilepsia 1990;31:642.