Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae

Journal of Antibiotics

Volumn 54, Issue 1, 2001, Pages 84-90

  Tsuchiya, E ^a   Yukawa, M ^a   Miyakawa, T ^a   Kimura, K I ^a   Takahashi, H ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTIBIOTIC AGENT; BORRELIDIN; BUFFER; CARBOXYL GROUP; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOHEXIMIDE; ENZYME INHIBITOR; FLAVONE DERIVATIVE; FLAVOPIRIDOL; FUNGAL DNA; FUNGAL ENZYME; FUNGAL PROTEIN; FUNGAL RNA; GALACTOSE; GLUCOSE; MACROLIDE; MATING HORMONE ALPHA FACTOR; METHIONINE; MONOCLONAL ANTIBODY; PHEROMONE DERIVATIVE; PURINE DERIVATIVE; RETINOBLASTOMA PROTEIN; SYNTHETASE; THREONINE TRANSFER RNA; TRANSFER RNA; TRICHLOROACETIC ACID; UNINDEXED DRUG;

ARTICLE; CELL CYCLE G1 PHASE; CELL GROWTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIPLOIDY; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME INHIBITION; EUKARYOTE; FUNGUS GROWTH; GROWTH INHIBITION; HAPLOIDY; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0035123160     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.84     Document Type: Article

References (21)

1. Cyclin-dependent kinases:engines, clocks and microprocessors
2. Regulation of CDK/cyclin complexes during the cell cycle
3. Cyclin dependent kinase regulation
4. The role of RB in cell cycle control
5. Control of eukaryotic cell cycle progress by phosphorylation of cyclin-dependent kinases
6. Preclinical and clinical development of cyclin-dependent kinase modulators
7. Borrelidin, a new antibiotic with anti-borrelia activity and penicillin enhancement properties
8. Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity from a species of Streptomyces (C2989)
9. Anti-viral activity of two antibiotics isolated from a species of Streptomyces
10. Borrelidin is an angiogenesis inhibitor; Disruption of angiogenic capillary vessels in a rat aorta matrix culture model
11. Biochemical and immunological characterization of threonyl-tRNA synthetase of two borrelidin-resistant mutants of Escherichia coli K12
12. Comparison of the Saccharomyces cerevisiae G1 cyclins: Cln3 may be an upstream activator of Cln1, Cln2 and other cyclins
13. The Saccharomyces cerevisiae NPS1 gene, a novel CDC gene which encodes a 160kDa nuclear protein involved in G2 phase control
14. Sequential gene function in the initiation of S. cerevisiae DNA synthesis
15. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
16. Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division
17. CDC33 encodes mRNA capbinding protein eIF-4E of Saccharomyces cerevisiae
18. G1 cyclins CLN1 and CLN2 repress the mating factor response pathway at Sart in the yeast cell cycle
19. Saccharomyces cerevisiae G1 cyclins differ in their intrinsic functional specificities
20. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors