AJI9561, a new cytotoxic benzoxazole derivative produced by Streptomyces sp

Journal of Antibiotics

Volumn 54, Issue 1, 2001, Pages 102-104

  Sato, S ^a   Kajiura, T ^a   Noguchi, M ^a   Takehama, K ^a   Kobayashi, T ^a   Tsuji, T ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONITRILE; AJ 19561; BENZOXAZOLE DERIVATIVE; CALCIUM CARBONATE; CHLOROFORM; CYTOTOXIC AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); FERRIC CHLORIDE; GLUCOSE; MAGNESIUM SULFATE; METHANOL; POTASSIUM DIHYDROGEN PHOSPHATE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER CELL CULTURE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG ISOLATION; ENZYME INHIBITION; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LEUKEMIA P 388; MYCELIUM; NOTE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STREPTOMYCES; STRUCTURE ANALYSIS;

STREPTOMYCES;

EID: 0035122815     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.102     Document Type: Note

References (4)

1. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties
2. UK-1, a novel cytotoxic metabolite from Streptomyces sp. 517-02. II. Structural elucidation
3. Methods for characterization of Streptomyces species
4. The novel bis(benzoxazole) cytotoxic natural product UK-1 is a magnesium ion-dependent DNA binding agent and inhibitor of human topoisomerase II