Ursodeoxycholic acid complexation with 2-hydroxypropyl-β-cyclodextrin increases ursodeoxycholic acid biliary excretion after single oral administration in rats

Pharmacology

Volumn 62, Issue 2, 2001, Pages 107-112

  Ventura, Paolo ^a   Panini, Rossana ^a   Montosi, Giuliana ^a   Garuti, Cinzia ^a   Vandelli, Maria ^a   Brunetti, Gabriele ^a   Tauschel, Horst Dietmar ^b   Pietrangelo, Antonello ^a   Salvioli, Gianfranco ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Dr Falk Pharma GmbH   (Germany)

Author keywords

Ursodeoxycholic acid administration, oral; Ursodeoxycholic acid, biliary recovery; Ursodeoxycholic acid 2 hydroxypropyl cyclodextrin complex

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; URSODEOXYCHOLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BILE DUCT FISTULA; BILIARY EXCRETION; COMPLEX FORMATION; CONTROLLED STUDY; DISSOLUTION; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CAPSULE; DRUG DOSAGE FORM; DRUG EXCRETION; DRUG FORMULATION; DRUG SOLUBILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; BETA-CYCLODEXTRINS; BILE; BILIARY FISTULA; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CYCLODEXTRINS; DRUG COMBINATIONS; MALE; RATS; RATS, SPRAGUE-DAWLEY; URSODEOXYCHOLIC ACID;

EID: 0035121565     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056080     Document Type: Article

References (33)

1. Metabolism of ursodeoxycholic acid in man
2. Pretreatment biliary lipid composition in white patients with radiolucent gallstones in the National Cooperative Gallstone Study
3. Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rats
4. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis
5. Dissolution of cholesterol gallstones by long-term administration of ursodeoxycholic acid
6. A multicenter controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC study group
7. Pharmacology of ursodeoxycholic acid, an enterohepatic drug
8. Clinical pharmacokinetics of therapeutic bile acids
9. Bioavailability, gastrointestinal transit, solubilization and faecal excretion of ursodeoxycholic acid in man
10. Pharmacokinetics of ursodeoxycholic acid in rat
11. Chemical properties of bile acids. III. Structure and solubility in water
12. pH-solubility relations of chenodeoxycholic and ursodeoxycholic acid: Physical-chemical basis for dissimilar solution and membrane phenomena
13. Aqueous solubility and acidity constant of cholic, deoxycholic, chenodeoxycholic and ursodeoxycholic acids
14. Effects of acute changes of bile acid pool composition on biliary secretion
15. 2-Hydroxypropyl-β-cyclodextrin complexation with ursodeoxycholate
16. One- and two-dimensional NMR study of complexation of ursodeoxycholic acid with β-cyclodextrin
17. The interaction of biliary acids with 2-hydroxypropyl-β-cyclodextrin in solution and in the solid state
18. Improvement of water solubility and dissolution of ursodeoxycholic and chenodeoxycholic acid by complexation with natural and modified β-cyclodextrins
19. Simultaneous microanalysis of biliary cholesterol, bile acids and fatty acids in lecithin using capillary column gas chromatography: An advantage to assess bile lithogenicity
20. Ileal excretion of bile acids: Comparison with biliary bile acid and effect of ursodeoxycholic acid treatment
21. Intestinal absorption of ursodeoxycholic acid in patients with extrahepatic biliary obstruction and bile drainage
22. Improved intestinal absorption of an enteric-coated sodium ursode-oxycholate formulation
23. Bile acids: Physico-chemical properties, function and activity
24. Intestinal absorption of ursodeoxycholic, glycoursodeoxy-cholic and tauroursodeoxycholic acids in rats
25. The pharmacokinetics of beta-cyclodextrin and hydroxypropyl-beta cyclodextrin in the rat
26. Fate of β-cyclodextrin in the human intestine
27. Intestinal safety of water-soluble beta cyclodextrins in pediatric oral solutions of spironolactone: Effects on human intestinal epithelial Caco-2 cells
28. Evaluation of the cytotoxicity of cyclodextrins and hydroxypropylated derivatives
29. Metabolism, pharmacokinetics and activity of a new 6-fluoro analogue of ursodeoxycholic acid in rats and hamsters
30. N-ethyl-tauroursodeoxycholic acid, a novel deconjugation-resistant bile salt analogue: Effects of acute feeding in the rat
31. Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate
32. Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats
33. Influence of ursodeoxycholic acid on biliary lipids