BHRF1 is highly conserved in primate virus analogues of Epstein-Barr virus

Intervirology

Volumn 44, Issue 1, 2001, Pages 55-58

  Williams, T Tracey ^a   Sale, Darleen ^a   Hazlewood, Sheila Ann ^a  

^a KEELE UNIVERSITY   (United Kingdom)

Author keywords

Apoptosis; Bcl 2; BHRF1; Epstein Barr virus; Herpesvirus pan; Herpesvirus papio

Indexed keywords

PROTEIN BCL 2; PROTEIN BHRF; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL TRANSFORMATION; EPSTEIN BARR VIRUS; GENE SEQUENCE; GENETIC CONSERVATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMATE; PRIORITY JOURNAL; PROTEIN DOMAIN; VIRUS GENE; VIRUS GENOME; VIRUS ISOLATION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CONSERVED SEQUENCE; GENES, VIRAL; HERPESVIRUS 4, HUMAN; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; PRIMATES; SEQUENCE ALIGNMENT; VIRAL PROTEINS; VIRUS LATENCY;

HERPESVIRIDAE; HERPESVIRUS PAPIO; HUMAN HERPESVIRUS 4; PAN (APE); PAPIO; PONGINE HERPESVIRUS 1; PRIMATES;

EID: 0035117094     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000050031     Document Type: Article

References (21)

1. Epstein-Barr virus
2. Epstein-Barr virus and its replication
3. Induction of Bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B-cells from programmed cell death
4. Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kB
5. Epstein-Barr virus-coded BHRF-1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
6. Epstein-Barr virus encodes a novel homologue of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak
7. Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex
8. The ability of BHRF1 to inhibit apoptosis is dependent on stimulus and cell type
9. The Epstein-Barr virus gene BHRF1, a homologue of the cellular Bcl-2 oncogene bcl-2, inhibits apoptosis induced by gamma radiation and chemotherapeutic drugs
10. Epstein-Barr-virus BHRF1 protein protects against cell-death induced by DNA-damaging agents and heterologous viral infection
11. BHRF1, a viral homolog of the bcl-2 oncogene, disturbs epithelial-cell differentiation
12. Functional differences between BHRF1, the Epstein-Barr virus-encoded Bcl-2 homologue, and Bcl-2 in human epithelial cells
13. BHRF-1 of Epstein-Barr virus, which is homologous to the human proto-oncogene bcl-2, is not essential for transformation of B-cell or for virus replication in vitro
14. BHRF-1, the Epstein-Barr virus gene with homology to Bcl-2, is dispensable for B lymphocyte transformation and virus replication
15. BHRF1, a viral homologue of the Bcl-2 oncogene, is conserved at both the sequence and functional level in different Epstein-Barr virus isolates
16. Distinction between Epstein-Barr virus type A (EBNA 2A) and type B (EBNA 2B) isolates extends to the EBNA 3 family of nuclear proteins
17. Geographic prevalence of two Epstein-Barr virus types
18. Biologic and antigenic characteristics of Epstein-Barr virus related herpesviruses of chimpanzees and baboons
19. Herpesvirus papio DNA is similar in organisation to Epstein-Barr virus DNA
20. DNA of Herpesvirus pan, a third member of the Epstein-Barr virus, Herpesvirus papio group
21. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax