IgG anti-LABD97 antibodies in bullous pemphigoid patients' sera react with the mid-portion of the BPAg2 ectodomain [1]

Journal of Investigative Dermatology

Volumn 116, Issue 2, 2001, Pages 348-350

  Egan, Conleth A ^e   Reddy, Daphne ^a   Nie, Zhuxiang ^b   Taylor, Ted B ^e   Schmidt, Linda A ^e   Meyer, Laurence J ^c   Petersen, Marta J ^e   Hashimoto, Takashi ^b   Marinkovich, M Peter ^a   Zone, John J ^d  

^a STANFORD UNIVERSITY   (United States)

^b KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Education and Clinical Center   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; EPITOPE; HYBRID PROTEIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G ANTIBODY; MEMBRANE PROTEIN; PROTEIN BPAG2; PUROMYCIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; CELL ADHESION; DNA LIBRARY; HUMAN; LETTER; NONHUMAN; PEMPHIGOID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING; SERUM;

EID: 0035115541     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01246.x     Document Type: Letter

References (15)

1. Properties of the collagen type XVII Ectodomain: Evidence for N-to C-terminal triple helix folding
2. Epitope spreading: Lessons from autoimmune skin diseases
3. Immunoblotting studies of linear IgA disease
4. Bullous pemphigoid sera that contain antibodies to BPAg2 also contain antibodies to LABD97 that recognize epitopes distal to the NC16A domain
5. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
6. Molecular mapping of a pathogenically relevant BP180 epitope associated with experimentally induced murine bullous pemphigoid
7. IgA antibodies of cicatricial pemphigoid sera specifically react with C-terminus of BP180
8. Affinity purification of antibodies from diazontized paper blots of heterogenous protein samples
9. IgG autoantibodies from bullous pemphigoid (BP) patients bind antigenic sites on both the extracellular and the intracellular domains of the BP antigen 180
10. The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases
11. Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosopholia embryos: Application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots
12. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
13. Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies
14. Identification of the cutaneous basement membrane zone antigen and isolation of antibody in linear immunoglobulin A bullous dermatosis
15. The 97 kDa linear IgA bullous disease antigen is identical to a portion of the extracellular domain of the 180 kDa bullous pemphigoid antigen BPAg2