Azide inhibits human cytochrome P-4502E1, 1A2, and 3A4

Alcoholism: Clinical and Experimental Research

Volumn 25, Issue 2, 2001, Pages 253-260

  Salmela, Katja S ^a   Tsyrlov, Ilya B ^a   Lieber, Charles S ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CYP1A2; CYP2E1; CYP3A4; Microsomal Ethanol Oxidizing System (MEOS); Sodium Azide

Indexed keywords

CATALASE; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; MICROSOME ENZYME; RESORUFIN DERIVATIVE; SODIUM AZIDE;

ALCOHOL OXIDATION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEALKYLATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HYDROXYLATION; KINETICS; LIVER METABOLISM; MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035112824     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2001.tb02206.x     Document Type: Article

References (17)

1. Characterization of the cytochrome P450-dependent monooxygenase system of hamster liver microsomes: Effect of prior treatment with ethanol and other xenobiotics
2. Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
3. Determination of p-nitrophenol hydroxylase activity of rat liver microsmomes by high-pressure liquid chromatography
4. Expression of mammalian cytochrome P450 using vaccinia virus
5. Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
6. Cytochrome P450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
7. Reconstitution of the microsomal ethanol oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption
8. The carbon monoxide-binding pigment of liver microsomes: II. Solubilization, purification, and properties
9. Isolation of P450 enzymes from human liver
10. Respective role of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system
11. Furafylline is a potent and selective inhibitor of cytochrome P4501A2 in man
12. NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of afiatoxins in human liver
13. Hepatic microsomal ethanol-oxidizing system (MEOS): Metabolic aspects and clinical implications
14. Hepatic microsomal alcoholoxidizing system: Affinity for methanol, ethanol, proparol, and butanol
15. Enzyme-kinetic and immunochemical characteristics of mouse cDNA-expressed, microsomal, and purified CYP1A1 and CYP1A2
16. Isoenzyme- and species-specific susceptibility of cDNA-expressed CYP1A P450s to different flavonoids
17. Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes