HNF-3β, C/EBPβ, and HNF-4 act in synergy to enhance transcription of the human apolipoprotein B gene in intestinal cells

DNA and Cell Biology

Volumn 20, Issue 2, 2001, Pages 67-74

  Antes, T J ^a   Levy Wilson, B ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTESTINE CELL; MUTAGENESIS; PRIORITY JOURNAL;

APOLIPOPROTEINS B; BASE COMPOSITION; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CACO-2 CELLS; CCAAT-ENHANCER-BINDING PROTEIN-BETA; DNA-BINDING PROTEINS; DRUG SYNERGISM; ENHANCER ELEMENTS (GENETICS); HEPATOCYTE NUCLEAR FACTOR 3-BETA; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; HUMANS; INTESTINES; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN BINDING; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0035112314     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/104454901750070265     Document Type: Article

References (21)

1. Identification and characterization of a 315-bp enhancer, located more than 55 kb 5′ of the apolipoprotein B gene, that confers expression in the intestine
2. Characterization of tissue-specific enhancer elements in the second intron of the human apolipoprotein B gene
3. Hepatocyte nuclear factor 1 and C/EBP are essential for the activity of the human apolipoprotein B gene second-intron enhancer
4. Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice
5. The enhanceosome and transcriptional synergy
6. Liver-enriched transcription factors and hepatocyte differentiation
7. CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor 4 and enhances apolipoprotein gene expression
8. Tissue-specific expression and developmental regulation of the rat apolipoprotein B gene
9. Control of apolipoprotein A1 gene expression through synergistic interactions between hepatocyte nuclear factors 3 and 4
10. Apolipoprotein B: Structural and metabolic heterogeneity
11. Transcriptional control of the humun apolipoprotein B gene in cultured cells and in transgenic animals
12. Nuclease-hypersensitive sites define a region with enhancer activity in the third intron of the human apolipoprotein B gene
13. DNA sequence of the human apolipoprotein B gene
14. Comparative analysis of sequences at the 5′ end of the human and mouse apolipoprotein B genes
15. Orphan receptor HNF-4 and bZip protein C/EBPα bind to overlapping regions of the apolipoprotein B gene promoter and synergistically activate transcription
16. Apolipoprotein B gene expression in a series of human apolipoprotein B transgenic mice generated with recA-assisted restriction endonuclease cleavage-modified bacterial artificial chromosomes: An intestine-specific enhancer element is located between 54 and 62 kilobases 5′ to the structural gene
17. Intestinal maturation in mice lacking CAAT/enhancer-binding protein alpha (C/EBP alpha)
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19. Similarities and differences in the function of regulatory elements at the 5′ end of the human apolipoprotein B gene in cultured hepatoma (HepG2) and colon carcinoma (CaCo-2) cells
20. Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily
21. Recent progress in understanding apolipoprotein B