Dynorphin A analogs containing a conformationally constrained phenylalanine derivative in position 4: Reversal of preferred stereochemistry for opioid receptor affinity and discrimination of κ vs. δ receptors

Chirality

Volumn 13, Issue 3, 2001, Pages 125-129

  Aldrich, Jane V ^a   Zheng, Qi ^a   Murray, Thomas F ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

(R) and (S) 2 aminotetralin 2 carboxylic acid (Atc); Opioid peptide; Solid phase peptide synthesis

Indexed keywords

2 AMINOTETRALIN 2 CARBOXYLIC ACID; 2 AMINOTETRALIN DERIVATIVE; DELTA OPIATE RECEPTOR; DYNORPHIN A DERIVATIVE; DYNORPHIN[1-11]; KAPPA OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; PHENYLALANINE DERIVATIVE; RADIOLIGAND; UNCLASSIFIED DRUG;

ARTICLE; DRUG RECEPTOR BINDING; LIGAND BINDING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR AFFINITY; STEREOCHEMISTRY;

2-NAPHTHYLAMINE; AMINO ACIDS; ANIMALS; DYNORPHINS; MICE; OPIOID PEPTIDES; PHENYLALANINE; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0035111402     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-636X(2001)13:3<125::AID-CHIR1008>3.0.CO;2-S     Document Type: Article

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