Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on κ receptor selectivity and potency

Journal of Medicinal Chemistry

Volumn 39, Issue 13, 1996, Pages 2456-2460

  Lung, Feng Di T ^a   Meyer, J P ^a   Lou, Bih Show ^a   Xiang, Li ^a   Li, Guigen ^a   Davis, Peg ^a   De Leon, Irene A ^a   Yamamura, Henry I ^a   Porreca, Frank ^a   Hruby, Victor J ^a,b  

^a UNIVERSITY OF ARIZONA   (United States)

^b Department of Chemistry ^*

Author keywords

[No Author keywords available]

Indexed keywords

DELTA OPIATE RECEPTOR; DYNORPHIN A DERIVATIVE; DYNORPHIN[1-11][3 DEXTRO ALANINE]AMIDE; DYNORPHIN[1-11]AMIDE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; OPIATE RECEPTOR; TRITIUM; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN HOMOGENATE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GUINEA PIG; ILEUM; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; BENZENEACETAMIDES; BRAIN; DYNORPHINS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALINS; GUINEA PIGS; ILEUM; MOLECULAR SEQUENCE DATA; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PYRROLIDINES; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029952033     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950655o     Document Type: Article

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