A structurally biased combinatorial approach for discovering new anti-picornaviral compounds

Chemistry and Biology

Volumn 8, Issue 1, 2001, Pages 33-45

  Tsang, Simon K ^a   Cheh, James ^b   Isaacs, Lyle ^b   Joseph McCarthy, Diane ^c   Choi, Seok Ki ^b   Pevear, Dan C ^d   Whitesides, George M ^b   Hogle, James M ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c PFIZER INC   (United States)

^d ViroPharma Incorporated   (United States)

Author keywords

Anti picornaviral; Capsid binding; High throughput; Screen

Indexed keywords

ANTIVIRUS AGENT; COAT PROTEIN; HYDROPHOBICITY; LIGAND BINDING; PICORNAVIRUS; SPECTROMETRY; VIRUS CAPSID; VIRUS PROTEIN; VIRUS RNA;

ANIMALS; ANTIVIRAL AGENTS; CAPSID; COMBINATORIAL CHEMISTRY TECHNIQUES; CYTOPATHOGENIC EFFECT, VIRAL; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HELA CELLS; HUMANS; PICORNAVIRIDAE; RADIOLIGAND ASSAY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MIRIDAE; PICORNAVIRIDAE; POLIOVIRUS; RHINOVIRUS; RNA VIRUSES;

EID: 0035110357     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(00)00053-3     Document Type: Article

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