Beneficial effects of low-dose prostacyclin on cat intestinal perfusion during endotoxemia as evaluated with microdialysis and oxygen transport variables

Critical Care Medicine

Volumn 29, Issue 2, 2001, Pages 351-358

  Möller, Alma D ^a   Grände, Per Olof ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Endotoxin; Glycerol; Intestinal circulation; Intestinal mucosa; Lactate; Microdialysis; Multiple organ failure; Oxygen transport; Prostacyclin; Pyruvate; Sepsis; Systemic inflammatory response syndrome

Indexed keywords

ENDOTOXIN; GLUCOSE; GLYCEROL; LACTIC ACID; OXYGEN; PROSTACYCLIN; PROSTACYCLIN DERIVATIVE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PH; BLOOD PRESSURE; CAT; CONTROLLED STUDY; DRUG EFFECT; ENDOTOXEMIA; INTESTINE PERFUSION; LACTATE BLOOD LEVEL; MICRODIALYSIS; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; SUPERIOR MESENTERIC ARTERY; VASCULAR RESISTANCE;

EID: 0035110016     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200102000-00025     Document Type: Article

References (45)

1. Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis
2. Physiology of the intestinal circulation
3. On the pathophysiology of intestinal ischemic injury
4. Endotoxin (LPS) increases mesenteric vascular resistance (MVR) and bacterial translocation (BT)
5. Sepsis/septic shock: Participation of the microcirculation: An abbreviated review
6. Cytopathic hypoxia in sepsis
7. Splanchnic and total body oxygen consumption differences in septic and injured patients
8. The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction
9. Multiple-organ-failure syndrome. The gastrointestinal tract: The "motor" of MOF
10. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation
11. Effects of the stable prostacyclin analogue iloprost on mesenteric blood flow in porcine endotoxic shock
12. The effects of prostacyclin on gastric intramucosal pH in patients with septic shock
13. Perioperative endotoxemia and bacterial translocation during major abdominal surgery: Evidence for the protective effect of endogenous prostacyclin?
14. The effects of prostacyclin on the adhesion of leukocytes to injured vascular endothelium
15. 2 and prostacyclin
16. 2): New aspects of an old substance in the treatment of critically ill patients
17. Low-dose prostacyclin has potent capillary permeability reducing effects in cat skeletal muscle in vivo
18. Pentoxiphylline protects splanchnic prostacyclin synthesis during mesenteric ischemia/reperfusion
19. The role of prostanoids in the feline intestinal vascular and central haemodynamic responses to i.v. infusion of live E. coli
20. Microdialysis - Principles and applications for studies in animals and man
21. Microdialysis in normal and injured human brain
22. Metabolite levels in human skeletal muscle and adipose tissue studied with microdialysis at low perfusion rates
23. Feline endotoxin shock: Effects on tissue histamine and histidine decarboxylase activity
24. Animal models of sepsis and shock: A review and lessons learned
25. Effect of lipopolysaccharide on intestinal intramucosal hydrogen ion concentration in pigs: Evidence of gut ischemia in a normodynamic model of septic shock
26. Lactic acidosis in sepsis: A commentary
27. Prostacyclin but not phentolamine increases oxygen consumption and skin microvascular blood flow in patients with sepsis and respiratory failure
28. Action of the stable prostacyclin analogue iloprost on microvascular tone and permeability in the hamster cheek pouch
29. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure [shock]
30. TNF binding protein prevents hyperlactatemia and inactivation of PDH complex in skeletal muscle during sepsis
31. Chronic infusion of interleukin-1 induces hyperlactatemia and altered regulation of lactate metabolism in skeletal muscle
32. Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis
33. Lactic acidosis in critical illness
34. Lactic acidosis: Tissue hypoxia and other causes
35. A concept for the introduction of cerebral microdialysis in neurointensive care
36. Splanchnic homeostasis during endotoxin challenge in the pig as assessed by microdialysis and tonometry
37. Comparison of brain tissue oxygen tension to microdialysis-based measures of cerebral ischemia in fatally head-injured humans
38. 2) on platelet behaviour, thrombus formation in vivo and bleeding time
39. Intravenous infusion of iloprost in arterial occlusive disease: Dose-dependent effects on skin microcirculation
40. W-nitro-L-arginine on early events following lipopolysaccharide injection: Observations in the hamster cheek pouch microcirculation
41. Iloprost improves the filtrability of stressed rabbit erythrocytes
42. Effects of prostacyclin analogs on the synthesis of tissue factor, tumor necrosis factor-alpha and interleukin-1 beta in human monocytic THP-1 cells
43. The therapeutic value of vasodilator prostaglandins in multiple organ failure associated with sepsis
44. Aerosolized prostacyclin and inhaled nitric oxide in septic shock - Different effects on splanchnic oxygenation?