Aerosolized prostacyclin and inhaled nitric oxide in septic shock - Different effects on splanchnic oxygenation?

Intensive Care Medicine

Volumn 22, Issue 9, 1996, Pages 880-887

  Eichelbronner O ^a   Reinelt, H ^a   Wiedeck, H ^a   Mezody M ^b   Rossaint, R ^c   Georgieff, M ^a   Radermacher, P ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Gastric intramucosal pH; Indocyanine green extraction; Nitric oxide; PCO2 gap; Prostacyclin; Septic shock; Splanchnic oxygenation

Indexed keywords

ADRENALIN; INDOCYANINE GREEN; NITRIC OXIDE; NORADRENALIN; PROSTACYCLIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL STUDY; FEMALE; GAS EXCHANGE; HEMODYNAMICS; HUMAN; INTENSIVE CARE; LUNG ARTERY PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NEBULIZER; PULMONARY HYPERTENSION; SEPTIC SHOCK; ULTRASOUND; UNIVERSITY HOSPITAL;

EID: 0029802279     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02044111     Document Type: Article

References (31)

1. Mythen MG, Webb AR (1994) The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction. Intensive Care Med 20:203-209
2. Bone RC and members of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference (1992). Definitions for sepsis and organ failure and guidelines for innovative therapies in sepsis. Crit Care Med 20:864-874
3. Radermacher P, Buhl R, Santak B, Klein J, Kniemeyer HW, Becker H, Tarnow J (1995) The effects of prostacyclin on gastric intramucosal pH in patients with septic shock. Intensive Care Med 21:414-421
4. VanderMeer TJ, Wang H, Fink MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23:1217-1226
5. Fridrich P, Krafft P, Koc D, Hammerle AF, Steltzer H (1995) Long-term nitric oxide inhalation in patients with severe sepsis and acute respiratory distress syndrome: Responders versus non-responders. Clin Int Care suppl to vol 6(2):19
6. Walmrath D, Schneider T, Pilch J, Grimminger F, Seeger W (1993) Aerosolized prostacyclin in adult respiratory distress syndrome. Lancet 342:961-962
7. Bein T, Pfeiffer M, Riegger G, Taeger K (1994) Continuous intraarterial measurement of oxygenation during aerosolized prostacyclin administration in severe respiratory failure. N Engl J Med 331:335-337
8. Walmrath D, Schneider T, Pilch J, Schermuly R, Grimminger F, Seeger W (1995) Effects of aerosolized prostacyclin in severe pneumonia - impact of fibrosis. Am J Respir Crit Care 151:724-730
9. Pappert D, Busch T, Gerlach H, Lewandowski K, Radermacher P, Rossaint R (1995) Aerosolized prostacyclin versus nitric oxide in children with severe acute respiratory distress syndrome. Anesthesiology 82:1507-1511
10. Gatecel C, Mebazaa A, Kong R, Guinard N, Kermarrec N, Matéo J, Payen D (1995) Inhaled nitric oxide improves hepatic tissue oxygenation in right ventricular failure: value of hepatic venous oxygen saturation monitoring. Anesthesiology 82:588-590
11. Keene AR, Cullen DJ (1983) Therapeutic intervention scoring system: update 1983. Crit Care Med 11:1-3
12. Goris RJ, Gimbrere JS (1985) Multiple organ failure: generalized autodestructive inflammation? Arch Surg 120: 1109-1115
13. Knaus WJ, Draper EA, Wagner DP, Zimmermann JE (1985) Prognosis in acute organ system failure. Ann Surg 202:685-693
14. Dhainaut JFA, Tenaillon A, Tulzo YL, Schlemmer B, Solet JP, Wolff M, Holzapfel L, Zehni F, Dreyfuss D, Mira JP, De Vathaire F, Guinot P (1994) Platelet-activating factor receptor antagonist BN52021 in the treatment of severe sepsis: a randomized, double-blind, placebo-controlled, multicenter clinical trial. Crit Care Med 22: 1721-1728
15. Jansen JRC, Schreuder JJ, Settels JJ, Kloek JJ, Versprille A (1990) An adequate strategy for the thermodilution technique in patients during mechanical ventilation. Intensive Care Med 16:422-425
16. Eichelbrönner O, Feist H, Georgieff M, Radermacher P (1995) Reliability of tonometric intramucosal PCO, measurement with a phosphate-buffer solution. Intensive Care Med 21:387-388
17. Fiddian-Green RG (1995) Gastric mucosal pH, tissue oxygenation and acid-base balance. Br J Anaesth 74: 591-606
18. Kuntz HD, Schregel W (1990) Indocyanine green: Evaluation of liver function - application in intensive care medicine. In: Lewis FR, Pfeiffer UJ (eds) Fiberoptics in critical care monitoring. Springer, Berlin Heidelberg New York, pp 57-62
19. Ruokonen E, Takala J, Kari A, Saxen H, Hansen EJ (1993) Regional blood flow and oxygen transport in septic shock. Crit Care Med 21:1296-1303
20. 2 as monitor of perfusion failure during hemorrhagic and anaphylactic shock. J Appl Physiol 76:572-577
21. 2 in intestine during low flow. J Appl Physiol 76:2443-2451
22. Smithies M, Yee TH, Jackson L, Beale R, Bihari D (1994) Protecting the gut and the liver in the critically ill: effect of dopexamine. Crit Care Med 22:789-795
23. Rimar S, Gillis N (1993) Selective pulmonary vasodilation by inhaled nitric oxide is due to hemoglobin inactivation. Circulation 88:2884-2887
24. Gibson QH, Roughton FJW (1957) The kinetics and equilibria of the reactions of nitric oxide with sheep hemoglobin. J Physiol (Lond) 136:507-526
25. Mutschler E (1991) Hormonales System. In: Arzneimittelwirkungen, Lehrbuch der Pharmakologie und Toxikologie. Wissenschaftliche Verlagsgesellschaft, Stuttgart, Band 2, pp 277-352
26. Baldus B, Müller B (1985) Iloprost improves the filtrability of stressed rabbit erythrocytes. Clin Hemorrheol 5:742
27. Bunting S, Gryglewsky R, Moncada S, Vane JR (1976) Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric coeliac arteries and inhibits platelet aggregation. Prostaglandins 12:897-913
28. Uusaro A, Ruokonen E, Takala J (1995) Estimation of splanchnic blood flow by the Fick principle in man and problems in the use of indocyanine-green. Cardiovasc Res 30:106-112
29. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328: 399-405
30. Gerlach H, Rosaint R, Pappert D, Falke KJ (1993) Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 23:499-502
31. Puypasset L, Rouby JJ (1995) Inhaled nitric oxide in acute respiratory failure. In: Vincent JL (ed) Yearbook of Intensive Care and Emergency Medicine. Springer, Berlin Heidelberg New York, pp 331-357