Conformation and ion channel properties of a five-helix bundle protein

Journal of Peptide Science

Volumn 7, Issue 1, 2001, Pages 41-49

  Dé, Emmanuelle ^a   Chaloin, Laurent ^b   Heitz, Annie ^c   Méry, Jean ^b   Molle, Gérard ^a   Heitz, Frédéric ^b  

^a Normandie Université   (France)

^b Centre National de la Recherche Scientifique   (France)

^c UNIV MONTPELLIER   (France)

Author keywords

Amphipathic peptide; Conformation; Five helix bundle; Ion channel

Indexed keywords

ALANINE; ARGININE; CATION; GLUTAMINE; GLYCINE; ION CHANNEL; LEUCINE; METHIONINE; MONOMER; PEPTIDE; PROTEIN; SPM PEPTIDE; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; ELECTRIC POTENTIAL; HYDROPHOBICITY; ION CONDUCTANCE; LIPID BILAYER; MEMBRANE; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

ALGORITHMS; AMINO ACID SEQUENCE; CIRCULAR DICHROISM; ION CHANNELS; LIPID BILAYERS; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE;

EID: 0035109565     PISSN: 10752617     EISSN: None     Source Type: Journal    
DOI: 10.1002/psc.293     Document Type: Article

References (40)

1. Antiviral activity of conjugates between poly(l-lysine) and synthetic oligodeoxyribonucleotides
2. Antiviral activity and possible mechanisms of action of oligonucleotides-poly(l-lysine) conjugates targeted to vesicular stomatitis virus mRNA and genomic RNA
3. Specific antiviral activity of a poly(l-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site
4. Oligonucleotide-poly(l-lysine)-heparin complexes: Potent sequence-specific inhibitors of HIV-1 infection
5. Intracellular routing and inhibitory activity of oligonucleopeptides containing a KDEL motif
6. Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide
7. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
8. The retro-inverso form of a homeobox-derived short peptide is rapidly internalised by cultured neurones: A new basis for an efficient intracellular delivery system
9. Synthesis and antiviral activity of peptide-oligonucleotide conjugates prepared by using N alpha-(bromo-acetyl)peptides
10. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
11. Loligomers: Design of de novo peptide-based intracellular vehicles
12. Conformations of primary amphipathic carrier peptides in membrane mimicking environments
13. Design of carrier peptide-oligonucleotide conjugates with rapid membrane translocation and nuclear localization properties
14. A new peptide vector for efficient delivery of oligonucleotides into mammalian cells
15. Effects on mollicutes (wall-less bacteria) of synthetic peptides comprising a signal peptide or a membrane fusion peptide, and a nuclear localization sequence (NLS) - A comparison with melittin
16. Solid-phase synthesis of melittin: Purification and functional characterization
17. Structure and function of channel-forming peptaibols
18. Correlation between anti-bacterial activity and pore sizes of two classes of voltage-dependent channel-forming peptides
19. Ionic channels formed by a primary amphipathic peptide containing a signal peptide and a nuclear localization sequence
20. A molecular model of membrane excitability
21. Statistical analysis of alamethicin channels in black lipid membranes
22. Antimicrobial peptide magainin I from Xenopus skin forms anion-permeable channels in planar lipid bilayers
23. Nature's rules and chemists' tools: A way for creating novel proteins
24. Template-assembled synthetic proteins with a four-helix-bundle topology. Total chemical synthesis and conformational studies
25. Template-assembled synthetic proteins designed to adopt a globular, four-helix bundle conformation form ionic channels in lipid bilayers
26. Template-assembled melittin: Structural and functional characterization of a designed, synthetic channel-forming protein
27. Synthesis of a template-associated peptide designed as a transmembrane ion channel former
28. Elucidating the folding problem of alpha-helices: Local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters
29. Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties
30. Ion channel reconstitution into lipid bilayer membranes on glass patch pipettes
31. Computed circular dichroism spectra for the evaluation of protein conformation
32. Engineering stabilized ion channels: Covalent dimers of alamethicin
33. Ion-channels of cyclic template-assembled alamethicins that emulate the pore structure predicted by barrel-stave model
34. Synporins - Synthetic proteins that emulate the pore structure of biological ionic channels
35. Porin from bacterial and mitochondrial outer membranes
36. Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor
37. The lowest conductance state of the alamethicin pore