Intracellular routing and inhibitory activity of oligonucleopeptides containing a KDEL motif

Molecular Pharmacology

Volumn 51, Issue 3, 1997, Pages 431-438

  Pichon, Chantal ^a   Arar, Khalil ^a,d   Stewart, Alistair J ^a,e   Dodon, Madeleine Duc ^b   Gazzolo, Louis ^b   Courtoy, Pierre J ^c   Mayer, Roger ^a   Monsigny, Michel ^a   Roche, Annie Claude ^a,f  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^d Sératec   (France)

^e Cantab Pharmaceuticals Ltd   (United Kingdom)

^f CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GAG PROTEIN; MESSENGER RNA; NUCLEOPROTEIN; OLIGONUCLEOTIDE; RECEPTOR ANTIBODY; TETRAPEPTIDE;

ARTICLE; CELL COMPARTMENTALIZATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG TARGETING; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HEP 2 CELL; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; PRIORITY JOURNAL;

EID: 0030894315     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Hélène, C., and J. J. Toulmé. Specific regulation of gene expression by antisense, sense and antigen nucleic acids. Biochim. Biophys. Acta 1049: 99-125 (1990).
2. Stein, C. A., and Y. C. Cheng. Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science (Washington D. C.) 261:1004-1012 (1993).
3. Stein, C. A., and J. S. Cohen. Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res. 48:2659-2668 (1988).
4. Capaccioli, S., G. Di Pasquale, E. Mini, T. Mazzei, and A. Quattrone. Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum. Biochem. Biophys. Res. Commun. 197:818-825 (1993).
5. Kabanov, A. V., S. V. Vinogradov, A. V. Ovcharenko, A. V. Krivonos, N. S. Melik-Nubarov, V. I. Kiselev, and E. S. Severin. A new class of antiviral antisense oligonucleotides combined with a hydrophobic substituent effectively inhibit influenza virus reproduction and synthesis of virus-specific protein in MDCK cells. FEBS Lett. 259:327-330 (1990).
6. Lemaitre, M., B. Bayard, and B. Lebleu. Specific antiviral activity of a poly (L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proc. Natl. Acad. Sci. USA 84:648-652 (1987).
7. Leonetti, J. P., P. Machy, G. Degols, B. Lebleu, and L. Leserman. Antibody-targeted liposomes containing oligodeoxyribonucleotides complementary to viral RNA selectively inhibit viral replication. Proc. Natl. Acad. Sci. USA 87:2448-2451 (1990).
8. Wagner, R. W. Gene inhibition using antisense oligodeoxynucleotides. Nature (Lond.) 372:333-335 (1994).
9. Zamecnik, P. C., and M. L. Stephenson. Inhibition of Rous sarcoma virus replication and cell transfection by a specific oligodeoxynucleotide. Proc. Natl. Acad. Sci. USA 75:280-284 (1978).
10. Goodchild, J., S. Agrawal, M. P. Civeira, P. S. Sarin, D. Sun, and P. C. Zamecnik. Inhibition of HIV replication by antisense oligodeoxynucleotides. Proc. Natl. Acad. Sci. USA 85:5507-5511 (1988).
11. Agrawal, S., and J. Y Tang. Gem-91: an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS. Antisense Res. Dev. 2:261-266 (1992).
12. Bonfils, E., C. Depierreux, P. Midoux, N. T. Thuong, M. Monsigny, and A. C. Roche. Drug targeting synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates. Nucleic Acids Res. 20:4621-4629 (1992).
13. Sdiqui, N., K. Arar, P. Midoux, R. Mayer, M. Monsigny, and A. C. Roche. Inhibition of human mammary cell line proliferation by membrane lectin-mediated uptake of ha-ras antisense oligodeoxynucleotide. Drug Delivery 2:63-72 (1995).
14. Munro, S., and H. R. B. Pelham. A C-terminal signal prevents secretion of luminal ER proteins. Cell 48:899-907 (1987).
15. Tang, B. L., S. H. Wong, X. L. Qi, S. H. Low, and W. Hong. Molecular cloning characterization, subcellular localization and dynamics of p23, the mammalian KDEL receptor. J. Cell Biol. 120:325-328 (1993).
16. Griffiths, G., M. Ericsson, J. Krijnse-Locker, T. Nilsson, B. Goud, H. D. Söling, B. L. Tang, S. H. Wong, and W. Hong. Localization of the Lys, Asp, Glu, Leu tetrapeptide receptor to the Golgi complex and the intermediate compartment in mammalian cells. J. Cell Biol. 127:1557-1574 (1994).
17. Seetharam, S., V. K. Chaudhary, D. FitzGerald, and I. Pastan. Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL. J. Biol. Chem. 266:17376-17381 (1991).
18. Wales, R., L. M. Roberts, and J. M. Lord. Addition of an endoplasmic reticulum retrieval sequence to ricin A chain significantly increases its cytotoxicity to mammalian cells. J. Biol. Chem. 268:23986-23990 (1993).
19. Sandvig, K., O. Garred, K. Prydz, J. V. Kozlov, S. H. Hansen, and B. van Deurs. Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum. Nature (Lond.) 358:510-512 (1992).
20. Pastan, I., V. Chaudhary, and D. J. Fitzgerald. Recombinant toxins as novel therapeutic agents. Annu. Rev. Biochem. 61:331-354 (1992).
21. Simpson, J. C., C. Dascher, L. M. Roberts, J. M. Lord, and W. E. Balch. Ricin cytotoxicity is sensitive to recycling between the endoplasmic reticulum and the Golgi complex. J. Biol. Chem. 270:20078-20083 (1995).
22. Marti, G., W. Egan, P. Noguchi, G. Zon, M. Matsukura, and S. Broder. Oligodeoxyribonucleotide phosphorothioate fluxes and localization in hematopoietic cells. Antisense Res. Dev. 2:27-39 (1992).
23. Tonkinson, J. L., and C. A. Stein. Patterns of intracellular compartmentalization, trafficking and acidification of 5′-fluorescein labeled phosphodiester and phosphorothioate oligodeoxynucleotides in HL60 cells. Nucleic Acids Res. 22:4268-4275 (1994).
24. Arar, K., A. M. Aubertin, A. C. Roche, M. Monsigny, and R. Mayer. Synthesis and antiviral activity of peptide-oligonucleotide conjugates prepared by using Nα-bromoacetyl peptides. Bioconjugate Chem. 6:573-577 (1995).
25. Sorger, P. K., and H. R. B. Pelham. The glucose regulated protein grp94 is related to heat shock protein hsp 90. J. Mol. Biol. 194:341-344 (1987).
26. Midoux, P., C. Mendès, A. Legrand, J. Raimond, R. Mayer, M. Monsigny, and A. C. Roche. Specific gene transfer mediated by lactosylated poly-L-lysine in hepatoma cells. Nucleic Acids Res. 21:871-878 (1993).
27. De Wet, J. R., K. V. Wood, M. De Luca, D. R. Helinski, and S. Subramani. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737 (1987).
28. Stein, C. A., J. L. Tonkinson, L. M. Zhang, L. Yakubov, J. Gervasoni, R. Taub, and S. A. Rotenberg. Dynamics of the internalization of phosphodiester oligodeoxynucleotides in HL60 cells. Biochemistry 32:4855-1861 (1993).
29. Midoux, P., A. C. Roche, and M. Monsigny. Quantitation of the binding, uptake and degradation of fluoresceinylated neoglycoprotein by flow cytometry. Cytometry 8:327-334 (1987).
30. Monsigny, M., A. C. Roche, and P. Midoux. Uptake of neoglycoproteins via membrane lectin(s) of L1210 cells evidenced by quantitative flow cytofluorometry and drug targeting. Biol. Cell 51:187-196 (1984).
31. Lowry, O. H., N. J. Roseburg, A. L. Farr, and R. J. Randall. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265-275 (1951).
32. Johnson, G. D., R. S. Davidson, K. C. McNamee, G. Russell, D. Goodwin, and E. J. Holborow. Fading of immunofluorescence during microscopy: a study of the phenomenon and its remedy. J. Immunol. Methods 55:231-242 (1982).
33. Banerjee, R., K. Sperber, T. Pizzella, and L. Mayer. Inhibition of HIV-1 productive infection in hepatoblastoma HepG2 cells by recombinant tumor necrosis factor α. AIDS 6:1127-1131 (1992).
34. Kuismanen, E., and J. Sarraste. Low temperature induced transport block as tool to manipulate membrane traffic. Methods Cell. Biol. 32:257-274 (1989).
35. Schweizer, A., J. A. Fransen, K. Matter, T. E. Kreis, L. Ginsel, and H. P. Hauri. Identification of an intermediate compartment involved in protein transport from endoplasmic reticulum to Golgi apparatus. Eur. J. Cell Biol. 53:185-196 (1990).
36. Akhtar, S., and R. L. Juliano. Cellular uptake and intracellular fate of antisense oligonucleotides. Trends Cell Biol. 2:139-158 (1992).
37. Vlassov, V. V., L. A. Balakireva, and L. A. Yakubov. Transport of oligonucleotides across natural and model membranes. Biochim. Biophys. Acta 1197:95-108 (1994).
38. Monsigny, M., A. C. Roche, P. Midoux, and R. Mayer. Glycoconjugates as carriers for specific delivery of therapeutic drugs and genes. Adv. Drug. Delivery Rev. 14:1-24 (1994).
39. Miesenböck, G., and J. E. Rothman. The capacity to retrieve escaped ER proteins extends to the trans-most cisterna of the Golgi stack. J. Cell Biol. 129:309-319 (1995).