Analysis of diversity of nucleotide and amino acid distributions in the VD and DJ joining regions in Ig heavy chains

Molecular Immunology

Volumn 37, Issue 14, 2000, Pages 827-835

  Hofle, Michael ^a   Linthicum, D Scott ^b   Ioerger, Thomas ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Delaware Water Gap Science Institute   (United States)

Author keywords

Antibody diversity; H3 loops; TdT; VDJ recombination

Indexed keywords

DNA NUCLEOTIDYLEXOTRANSFERASE; IMMUNOGLOBULIN HEAVY CHAIN; NUCLEOTIDE;

AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; GENE INSERTION SEQUENCE; GENETIC VARIABILITY; IMMUNOGLOBULIN GENE; PRIORITY JOURNAL; RNA TRANSLATION; SEQUENCE ANALYSIS;

EID: 0035108544     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0161-5890(00)00110-3     Document Type: Article

References (22)

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2. Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells
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5. The Protein Data Bank
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8. Molecular aspects of B-lymphocyte activation
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10. Mice lacking TdT: Mature animals with an immature lymphocyte repertoire
11. Kabat database and its applications: 30 years after the first variability plot
12. Identical V region amino acid sequences and segments of sequences in antibodies of different specificities. Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites
13. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
14. Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes
15. Junctional sequences of T cell receptor gamma delta genes: Implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining
16. Increased frequency of N-region insertion in a murine pre-B-cell line infected with a terminal deoxynucleotidyl transferase retroviral expression vector
17. Somatic generation of antibody diversity