Antitumor activity of benzamide riboside and its combination with cisplatin and staurosporine

European Journal of Pharmaceutical Sciences

Volumn 12, Issue 4, 2001, Pages 387-394

  Rauko, Peter ^a   Novotny, Ladislav ^b   Dovinova, Ima ^a   Hunakova, Luba ^a   Szekeres, Thomas ^c   Jayaram, Hiremagalur N ^d  

^a CANCER RESEARCH INSTITUTE   (Slovakia)

^b KUWAIT UNIVERSITY   (Kuwait)

^c UNIVERSITY OF VIENNA   (Austria)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Benzamide riboside; Cisplatin; Cytotoxicity; Murine leukemia cells; Staurosporine

Indexed keywords

BENZAMIDE DERIVATIVE; BENZAMIDE RIBOSIDE; CISPLATIN; DNA FRAGMENT; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CHEMOSENSITIVITY; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; LEUKEMIA; LEUKEMIA L 1210; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CISPLATIN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; LEUKEMIA L1210; MICE; MICE, INBRED DBA; NUCLEOSIDES; STAUROSPORINE; SURVIVAL RATE;

EID: 0035108339     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00180-9     Document Type: Article

References (33)

1. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia
2. Multi-drug effect analysis
3. Comparison of ability of protein kinase C inhibitors to arrest cell growth and to alter cellular protein kinase C localization
4. Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells
5. Rapid one step staining procedures for analysis of cellular DNA and protein by single and dual laser flow cytometry
6. Activation of programmed cell death by anticancer agents: cisplatin as a model system
7. Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and non-proliferating immature thymocytes
8. Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation
9. Induction of apoptosis through the PKC pathway in cultured dermal papilla fibroblasts
10. Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation
11. Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases
12. Cytotoxicity and characterization of an active metabolite of benzamide riboside, a novel inhibitor of IMP dehydrogenase
13. Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IPM dehydrogenase, with tiazofurin and selenazofurin
14. Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells
15. Enhancement of the antiproliferative effects of cis-diamminedichloroplatinum(II) and nitrogen mustard by inhibitors of protein kinase C
16. Tyrosine kinase inhibitor-induced differentiation of K-562 cells: alterations of cell cycle and cell surface phenotype
17. Staurosporine enhanced benzamide riboside-induced apoptosis in human multidrug-resistant promyelocytic leukemia cells (HL-60/VCR) in vitro
18. Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells
19. Schedule-dependent synergistic action of tiazofurin and dipyridamole on hepatoma 3924A cells
20. Biochemical consequences of resistance to a recently discovered IMP dehydrogenase inhibitor, benzamide riboside, in human myelogenous leukemia K562 cells
21. Consequences of IMP dehydrogenase inhibition, and its relationship to cancer and apoptosis
22. Abrogation of a kinase-mediated G1 cell arrest point is a late event in the neoplastic progression of human fibroblasts transfected with the SV40 large T antigen gene
23. Synthesis and cytotoxicity of C-glycosidic nicotinamide riboside analogues
24. Induction of apoptosis by transforming growth factor beta 1 in glioma and trigeminal neurinoma cells
25. Interaction of cytocidal drugs and the inhibition of caspase-3 by 3-nitrosobenzamide
26. Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines
27. Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA
28. Pentoxifylline stimulates drug-induced apoptosis in leukemic cells
29. Metabolism and action of benzamide riboside in Chinese hamster ovary cells
30. Effects of protein kinase C inhibitor, staurosporine derivative CGP 41 251, on cell cycle, DNA synthesis and drug uptake in neoplastic cell lines
31. Staurosporine induces telophase arrest and apoptosis blocking mitosis exit in human Chang liver cells
32. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells
33. A mechanism of cisplatin action: antineoplastic effect through inhibition of neovascularization