Frontotemporal lobar degeneration: An update on clinical, pathological and genetic findings

Gerontology

Volumn 47, Issue 1, 2001, Pages 1-8

  Tolnay, Markus ^a,b   Probst, A ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Frontotemporal dementia; Frontotemporal lobar degeneration; FTDP 17; Motor neuron disease; Pick's disease; Tau gene mutation; Tauopathy

Indexed keywords

TAU PROTEIN; UBIQUITIN;

ALZHEIMER DISEASE; APHASIA; BRAIN DEGENERATION; CELL INCLUSION; CHROMOSOME 17; DEGENERATIVE DISEASE; FRONTAL LOBE; FRONTOTEMPORAL DEMENTIA; GENE MUTATION; GLIA CELL; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MICROTUBULE; MOTOR NEURON DISEASE; NERVE CELL; NEURITE; NEUROPATHOLOGY; PARKINSONISM; PERIKARYON; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; REVIEW; TAUOPATHY; TEMPORAL LOBE;

AGED; BRAIN; CHROMOSOMES, HUMAN, PAIR 17; DEMENTIA; HUMANS; LINKAGE (GENETICS); PARKINSONIAN DISORDERS; TAU PROTEINS;

EID: 0035105957     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000052763     Document Type: Review

References (51)

1. Degenerative non-Alzheimer dementias
2. Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB International Workshop
3. Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
4. Review: Tau protein pathology in Alzheimer's disease and related disorders
5. Clinical and neuropathological criteria for fronto-temporal dementia
6. Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
7. Semantic dementia: A form of circumscribed cerebral atrophy
8. Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy
9. Slowly progressive aphasia without generalized dementia
10. Primary progressive aphasia: Longitudinal course, neuropsychological profile and language features
11. Progressive language disorder due to lobar atrophy
12. Clinical and pathological overlap between frontotem-poral dementia, primary progressive aphasia and corticobasal degeneration: The Pick complex
13. Pick's disease: A modern approach
14. Specific pathological tau protein variants characterize Pick's disease
15. Pick's disease: Hyperphosphorylated tau protein segregates to the somatoaxonal compartment
16. Glial inclusions in CNS degenerative diseases
17. Molecular classification of the dementias
18. Dementia lacking distinctive histologic features: A common non-Alzheimer degenerative dementia
19. Dementia lacking distinctive histopathology: Clinico-pathological evaluation of 32 cases
20. The new neuropathology of degenerative frontotemporal dementias
21. Frontal lobe degeneration: Novel ubiquitin-immunoreactive neurites within frontotemporal cortex
22. Presenile dementia with motor neuron disease in Japan: A new entity?
23. Frontal lobe dementia and motor neuron disease
24. New ubiquitin-positive intraneuronal inclusions in the extramotor cortices in patients with amyotrophic lateral sclerosis
25. Hippocampal and neocortical ubiquitin immunoreactive inclusions in amyotrophic lateral sclerosis with dementia
26. Motor neurone disease-inclusion dementia
27. Ubiquitin-immunohistochemical investigation of atypical Pick's disease without Pick bodies
28. Search for a mutation in the tau gene in a Swiss family with fron-totemporal dementia
29. Familial fronto-temporal dementia with ubiquitin inclusion bodies and without motor neuron disease
30. Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions
31. Dementia as the most common presentation of cortical-basal ganglionic degeneration
32. Clinical and pathological evidence for a frontal variant of Alzheimer's disease
33. Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22
34. Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
35. Phenotypic variation in hereditary fronto-temporal dementia with tau mutations
36. Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
37. Frontotemporal dementia and parkinsonism linked to chromosome 17: A new group of tauopathies
38. Association of missense and 5)-splice site mutations in tau with the inherited dementia FTDP-17
39. Tau is a candidate gene for chromosome 17 fronto-temporal dementia
40. Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
41. Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease
42. Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles
43. Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
44. Tau gene mutation G389R causes a tauopathy with abundant Pick body-like inclusions and axonal deposits
45. Familial aggregation in frontotemporal dementia
46. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands
47. Familial non-specific dementia maps to chromosome 3
48. Molecular genetic characterisation of frontotemporal dementia on chromosome 3
49. A new case of frontotempo-ral dementia and parkinsonism resulting from an intron 10 +3-splice site mutation in the tau gene: Clinical and pathological features
50. Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene. Expansion of the disease phenotype caused by tau gene mutations