Early developmental expression pattern of retinoblastoma tumor suppressor mRNA indicates a role in the epithelial-to-mesenchyme transformation of endocardial cushion cells

Developmental Dynamics

Volumn 220, Issue 3, 2001, Pages 198-211

  Wagner, Michael ^a,b   Miles, Kathryn ^a   Siddiqui, M A Q ^a  

^a SUNY Downstate Medical Center   (United States)

^b SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Alternative splicing of RNA; Cardiac septation; Cyclins and cyclin dependent kinases; Endocardial cushion cells; Epicardium; Epithelial to mesenchyme transformation; Hepatocyte growth factor scatter factor; Retinoblastoma tumor suppressor; Somitic myotome

Indexed keywords

CYCLIN DEPENDENT KINASE; RETINOBLASTOMA PROTEIN; RNA; SCATTER FACTOR;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CELL TRANSFORMATION; CHICKEN; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; HEART MUSCLE CELL; IN SITU HYBRIDIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; BASE SEQUENCE; CHICK EMBRYO; CLONING, MOLECULAR; DNA PRIMERS; DNA, COMPLEMENTARY; ENDOCARDIUM; EPITHELIUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, RETINOBLASTOMA; IN SITU HYBRIDIZATION; MESODERM; MOLECULAR SEQUENCE DATA; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; TISSUE DISTRIBUTION;

GALLUS GALLUS;

EID: 0035105924     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0177(20010301)220:3<198::AID-DVDY1103>3.0.CO;2-T     Document Type: Article

References (37)

1. Retinoblastoma protein contains a C-terminal motif that targets it for phosphorylation by cyclin-cdk complexes
2. Co-expression of the HGF/SF and c-met genes during early mouse embryogenesis precedes reciprocal expression in adjacent tissues during organogenesis
3. Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein
4. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
5. Structure and expression of the chicken retinoblastoma gene
6. Epithelial-mesenchymal transformation in atrioventricular cushion tissue morphogenesis
7. The retinoblastoma protein and the regulation of cell cycling
8. Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
9. Molecular regulation of atrioventricular valvuloseptal morphogenesis
10. Characterization of a chicken cDNA encoding the retinoblastoma gene product
11. The ability of agrin to cluster AChRs depends on alternative splicing and on cell surface proteoglycans
12. Induction of cyclin D1 overexpression by activated ras
13. A series of normal stages in the development of the chick embryo
14. Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein
15. Identification of early postmitiotic cells in distinct embryonic sites and their possible roles in morphogenesis
16. Neural crest and cardiovascular patterning
17. Human retinoblastoma susceptibility gene: Cloning, identification, and sequence
18. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
19. Use of 6-diazo-5-oxo-L-norleucine to study interaction between myocardial glycoconjugate secretion and endothelial activation in the early embryonic chick heart
20. Mechanisms of segmentation, septation, and remodeling of the tubular heart: Endocardial cushion fate and cardiac looping
21. Cyclin-dependent kinases: Engines, clocks, and microprocessors
22. In situ hybridization analysis of chick embryos in whole mount and tissue sections
23. Two myogenic lineages within the developing somite
24. Splicing of messenger RNA precursors
25. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
26. Contribution of the primitive epicardium to the subepicardial mesenchyme in hamster and chick embryos
27. The origin of the subepicardial mesenchyme in the avian embryo: An immunohistochemical and quail-chick chimera study
28. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
29. The retinoblastoma protein: More than a tumor suppressor
30. Cell multiplication rates during development of the primitive cardiac tube in the chick embryo
31. Hepatocyte growth factor expression in the developing myocardium: Evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression
32. Expression of HGF/SF, HGF/MSP and c-met suggests new functions during chick development
33. Organization and function of early specialized myocardium
34. Myocardialization of the cardiac outflow tract
35. The retinoblastoma protein and cell cycle control
36. Regulation of the cell cycle machinery by oncogenic ras