Effects of mercuric chloride exposure on the glutamate uptake by cultured retinal pigment epithelial cells

Toxicology in Vitro

Volumn 15, Issue 1, 2001, Pages 7-12

  Toimela, T A ^a   Tahti H ^a  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

Calcium; Glutamate uptake; Mercury; RPE

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; CALCIUM; CHELERYTHRINE CHLORIDE; GLUTAMIC ACID; HEPARIN; LAVENDUSTIN A; MANOALIDE; MERCURIC CHLORIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; OXIDOREDUCTASE; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C ACTIVATOR SC10; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; MITOCHONDRION; NONHUMAN; PIGMENT EPITHELIUM; PROTEIN CONTENT; PROTEIN TRANSPORT; SWINE;

ANIMALS; CALCIUM; CELL CULTURE TECHNIQUES; DISINFECTANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; HUMANS; MERCURIC CHLORIDE; PIGMENT EPITHELIUM OF EYE; PROTEIN KINASE C; SWINE;

SUS SCROFA;

EID: 0035105251     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(00)00057-6     Document Type: Article

References (50)

1. Glutamate: A potential mediator of inorganic mercury neurotoxicity
2. Mercury neurotoxicity: Mechanisms of blood-brain barrier transport
3. Glutamate and GABA in retinal circuitry
4. Inhibition of phosphoinositide-specific phospholipase C by manoalide
5. Differences in cadmium and mercury uptakes by hepatocytes: Role of calcium channels
6. Diversity of glutamate receptors in the mammalian retina
7. In vitro evidence for the role of glutamate in the CNS toxicity of mercury
8. Inhibition of amino acid transport and protein synthesis by HgCl2 and methylmercury in astrocytes: Selectivity and reversibility
9. A review of normal concentrations of mercury in human blood
10. Activation of high-affinity uptake of glutamate by phorbol esters in primary glial cell cultures
11. Phosphorylation and modulation of brain glutamate transporters by protein kinase C
12. Effects of excitatory amino acids on phosphoinositide metabolism in frog retina
13. Glutamate neurotoxicity and diseases of the nervous system
14. Excitotoxic cell death
15. A human retinal pigment epithelial cell line that retains epithelial characteristics after prolonged culture
16. Reconstitution of the photoreceptor-pigment epithelium interface: L-glutamate stimulation of adhesive interactions and rod disc shedding after recombination of dissociated Xenopus laevis eyecups
17. Coincidence of L-glutamate/L-aspartate transporter (GLAST) and glutamine synthetase (GS) immunoreactions in retinal glia: Evidence for coupling of GLAST and GS in transmitter clearance
18. Mercury accumulation in the eye following administration of methylmercury
19. Excitatory amino acid-induced inositol phosphate formation in cultured retinal pigment epithelium
20. Accumulation of methylmercury and inorganic mercury in the brain
21. Regulation of the Na+-dependent high affinity glutamate/aspartate transporter in cultured Bergmann glia by phorbol esters
22. Cognitive performance of children prenatally exposed to "safe" levels of methylmercury
23. Stimulation of photoreceptor disc shedding and pigment epithelial phagocytosis by glutamate, aspartate, and other amino acids
24. Biological monitoring of exposure to metallic mercury
25. ROS ingestion by RPE cells is turned off by increased protein kinase C activity and by increased calcium
26. Chelerythrine is a potent and specific inhibitor of protein kinase C
27. Amino acids in neurotransmission and disease
28. Sensitivity of the binding sites on glutamate transporters to neurotoxic agents
29. Selective inhibition of glutamate uptake by mercury in cultured mouse astrocytes
30. Excitatory amino acid receptors in membranes from cultured human retinal pigment epithelium
31. Mechanism of tamoxifens retinal toxicity studied in pig pigment epithelial cell cultures
32. Mercury levels in food and its intake in high-risk population groups
33. Transmitter circuits in the vertebrate retina
34. Na(+)-dependent glutamate transporter in human retinal pigment epithelial cells
35. Mercuric chloride uncouples glutamate uptake from the countertransport of hydroxyl equivalents
36. The Muller cell: A functional element of the retina
37. The release and uptake of excitatory amino acids
38. The toxic effects of glutamate and related compounds in the retina and the brain
39. Protein kinase C activation inhibits glutamate transport by endothelial cells
40. Modulation of protein kinase C by heavy metals
41. Sensitive indicators of inorganic mercury toxicity
42. Glutamate and taurine uptake by retinal pigment epithelium during rat development
43. Glutamate release by the intact light-responsive photoreceptor layer of the Xenopus retina
44. Metabotropic glutamate receptors in brain function and pathology
45. Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway
46. Effects of inorganic and organic mercury on intracellular calcium levels in rat T lymphocytes
47. Glutamate-stimulated proliferation of rat retinal pigment epithelial cells
48. Mercury accumulation in the squirrel monkey eye after mercury vapour exposure
49. Retinal protein kinase C
50. Inhibition of calcium transport by mercury salts in rat cerebellum and cerebral cortex in vitro