The cytoskeleton-associated TCR ζ chain is constitutively phosphorylated in the absence of an active p56lck form

European Journal of Immunology

Volumn 31, Issue 2, 2001, Pages 580-589

  Caplan, Steve ^a   Almogi Hazan, Osnat ^b   Ezernitchi, Anala ^b   Manaster, Efrat ^b   Gazit, Aviv ^c   Baniyash, Michal ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b HEBREW UNIVERSITY   (Israel)

^c Department of Organic Chemistry ^*  (Israel)

Author keywords

Cytoskeleton; Signaling; T cell; TCR

Indexed keywords

DETERGENT; PEPTIDE; PROTEIN TYROSINE KINASE; RECEPTOR SUBTYPE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ARTICLE; CELL FUNCTION; CELL SURFACE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SOLUBILITY; T LYMPHOCYTE ACTIVATION;

ANIMALS; CYTOSKELETON; FEMALE; ISOELECTRIC POINT; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL;

EID: 0035105239     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200102)31:2<580::AID-IMMU580>3.0.CO;2-H     Document Type: Article

References (39)

1. Differential signaling by lymphocyte antigen receptors
2. Adapter proteins in lymphocyte antigen-receptor signaling
3. Association of the Fyn protein-tyrosine kinase with the T-cell receptor
4. fyn tyrosine kinase associated with multiple T cell receptor subunits through its unique amino-terminal domain
5. ZAP-70: A 70 kD protein-tyrosine kinase that associates with the TCR ζ chain
6. Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 ζ chain
7. Interaction of Shc with the ζ chain of the T cell receptor upon T cell activation
8. Ligation of the T-cell receptor (TCR) induces association of hSoS1, ZAP-70, phospholipase C-gamma 1, and other phospho-proteins with Grb2 and the zeta-chain of the TCR
9. SH3-an abundant protein domain in search of a function
10. Multisubunit receptors in the immune system and their association with the cytoskeleton: In search of functional significance
11. Cell-surface-expressed T-cell antigen receptor ζ chain is associated with the cytoskeleton
12. Normal T cells express two T cell antigen receptor populations, one of which is linked to the cytoskeleton via ζ chain and displays a unique activation-dependent phosphorylation pattern
13. Searching for significance in TCR-cytoskeleton interactions
14. Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon activation of mature T lymphocytes
15. Qualitatively distinct signaling through T cell antigen receptor subunits
16. Fidelity of T cell activation through multistep T cell receptor phosphorylation
17. ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: The tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
18. The role of tyrosine phosphorylation in the interaction of cellular tyrosine kinases with the T cell receptor zeta chain tyrosine-based activation motif
19. Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation
20. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor
21. Profound block in thymocyte development in mice lacking p56lck
22. Abnormal tyrosine phosphorylation of T-cell receptor in lymphoproliferative disorders
23. Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes
24. lck associated with glycolipid-enriched membrane domains
25. The role of lipid rafts in T cell antigen receptor (TCR) signalling
26. Membrane compartmentation is required for efficient T cell activation
27. Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains
28. Clusters of glycolipid and glycosylphosphatidylinositol-anchored proteins in lymphoid cells: Accumulation of actin regulated by local tyrosine phosphorylation
29. Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation
30. Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface
31. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation
32. T cell antigen receptor ubiquitination is a consequence of receptor-mediated tyrosine kinase activity
33. pp56Lck mediates TCR zeta-chain binding to the microfilament cytoskeleton
34. Vab is a regulator of cytoskeletal reorganization mediated by the T-cell receptor
35. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction
36. Identification of a monoclonal antibody specific for a murine T3 polypeptide
37. Monoclonal antibodies defining distinctive human T cell surface antigens
38. A new subunit of the human T-cell antigen receptor complex
39. Surface expression of a T cell receptor data (TCR-beta) chain in the absence of TCR-alpha, -delta, and -gamma proteins