Effect of the noncompetitive NMDA antagonists MK-801 and ketamine on the spastic Han-Wistar mutant: A rat model of excitotoxicity

Developmental Neuroscience

Volumn 23, Issue 1, 2001, Pages 31-40

  Brunson, Kristen L ^a   Khanna, Aparna ^a   Cromwell, Howard C ^b   Cohen, Randy W ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cerebellum; Glutamate receptors; Hippocampus; Neuroprotection

Indexed keywords

DIZOCILPINE; GLUTAMATE RECEPTOR; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONTROLLED STUDY; HIPPOCAMPUS; MOTOR PERFORMANCE; NERVE CELL DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT;

ANIMALS; CELL SURVIVAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HIPPOCAMPUS; KETAMINE; LONGEVITY; MUSCLE SPASTICITY; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PURKINJE CELLS; PYRAMIDAL CELLS; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0035105238     PISSN: 03785866     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048694     Document Type: Article

References (57)

1. The role of GABA receptors in the spastic Han-Wistar degeneration
2. MK-801 differentially affects dopamine D1 and D2 receptor agonist-induced behavioral tolerance and desensitization
3. Mechanisms of excitotoxicity in neurologic diseases
4. A, NMDA, andAMPA receptors: A developmentally regulated 'menage a trois'
5. 2+ entry via AMPA/KA receptors and excitotoxicity in cultured cerebellar Purkinje cells
6. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
7. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
8. Glutamate neurotoxicity and diseases of the nervous system
9. Calcium still center stage in hypoxic ischemia neuronal death
10. Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
11. Methods for determining numbers of cells and synapses: A case for more uniform standards of review
12. Development of morphological and physiological alterations in the hippocampus of the spastic Han-Wistar rat
13. Altered excitatory amino acid function and morphology of the cerebellum of the spastic Han-Wistar rat
14. Effect of glutamate, aspartate and related derivatives on cerebellar Purkinje cell dendrites in the rat: An in vitro study
15. Differences in results from in vivo and in vitro studies on the use-dependency of N-methyl-D-aspartate antagonism by MK-801 and other phencyclidine receptor ligands
16. A receptor complex and potentiates flurazepam's antiseizure efficacy
17. Pathological effects of MK-801 in the rat posterior cingulate/retrosplenial cortex
18. Systemic administration of MK-801 prevents N-methyl-D-aspartate-induced neuronal degeneration in rat brain
19. Chronic morphine decreases calbindin D28k immunoreactivity in a subset of cerebellar Purkinje neurons in rat brain
20. Identification of a site in glutamate receptor subunits that controls calcium permeability
21. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
22. 3H]CNQX in the human cerebellum during development and aging
23. The spastic Han-Wistar rat: A genetic model of amino acid-induced excitotoxicity
24. Effects of optical isomers of ketamine on excitation of cat and rat spinal neurons by amino acids and acetylcholine
25. Intracellular injections of EGTA block induction of hippocampal long-term potentiation
26. Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy, with particular reference to the temporal lobes
27. Decreased GluR2(B) receptor subunit mRNA expression in cerebellar neurons at risk for degeneration
28. Excitatory amino acid neurotoxicity and neurodegenerative disease
29. 2+ release from intracellular stores induced by afferent stimulation of CA3 pyramidal neurons in hippocampal slices
30. The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system
31. Interaction of the NMDA receptor noncompetitive antagonist MK-801 with model and native membranes
32. Molecular cloning and characterization of the rat NMDA receptor
33. Purkinje cell survival is differentially regulated by metabotropic and ionotropic excitatory amino acid receptors
34. The neuroprotective effects of non-NMDA antagonists in the cerebellum of the spastic Han-Wistar mutant
35. Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate
36. Inciting excitotoxic cytocide among central neurons
37. MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain
38. Brain damage in mice from voluntary ingestion of glutamate and aspartate
39. Spontaneous occurrence of spastic paresis in Han-Wistar rats
40. Sensory neuron number in neonatal and adult rats estimated by means of stereologic and profile-based methods
41. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death
42. Glutamate and the pathophysiology of hypoxia-ischemic brain damage
43. Behavior of hypertensive and hyperactive rat strains: Hyperactivity is not unitarily determined
44. Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study
45. Mechanisms underlying the neuropathological consequences of epileptic activity in the rat hippocampus in vitro
46. Neuronal degeneration in hippocampus and cerebellum of mutant spastic Han-Wistar rats
47. The distribution of the NMDA R1 subunit in the rat hippocampus - An immunocytohistochemical study
48. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist
49. 3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes
50. The interaction between MK-801 and receptors for N-methyl-D-aspartate: Functional consequences
51. Spatial distribution of potentiated synapses in hippocampus: Dependence on cellular mechanisms and network properties
52. Excitatory amino acid receptors in the brain: Membrane binding and receptor autoradiographic approaches
53. Neuronal cell loss in heterozygous staggerer mutant mice: A model for genetic contributions to the aging process