Recognition of the Lck tyrosine kinase as a tumor antigen by cytotoxic T lymphocytes of cancer patients with distant metastases

European Journal of Immunology

Volumn 31, Issue 2, 2001, Pages 323-332

  Harashima, Nanae ^a   Tanaka, Koji ^a   Sasatomi, Teruo ^a   Shimizu, Kanako ^a   Miyagi, Yoshiaki ^a   Yamada, Akira ^a   Tamura, Mayumi ^a   Yamana, Hideaki ^a   Itoh, Kyogo ^a   Shichijo, Shigeki ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cancer vaccine; CTL; Lck; Metastatic cancer; Peptide

Indexed keywords

EPITOPE; HLA ANTIGEN CLASS 1; PEPTIDE DERIVATIVE; PROTEIN P56; PROTEIN TYROSINE KINASE; TUMOR ANTIGEN;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CANCER PATIENT; CELL FUNCTION; CELL MATURATION; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; EPITHELIUM CELL; GENETIC ANALYSIS; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MALIGNANT TRANSFORMATION; METASTASIS; NUCLEOTIDE SEQUENCE; ONCOGENE SRC; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; STEM CELL; T LYMPHOCYTE; TREATMENT PLANNING;

ANTIGENS, NEOPLASM; EPITOPES; HEMATOPOIETIC STEM CELLS; HLA-A ANTIGENS; HLA-A2 ANTIGEN; HUMANS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); NEOPLASM METASTASIS; NEOPLASMS; PEPTIDE FRAGMENTS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR CELLS, CULTURED;

EID: 0035105231     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200102)31:2<323::AID-IMMU323>3.0.CO;2-0     Document Type: Article

References (23)

1. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
2. A gene encoding an antigen recognized by cytolytic T lymphocyes on a human melanoma
3. A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes
4. A new gene coding for a protein possessing shared tumor epitopes capable of inducing cytotoxic T lymphocytes in cancer patients
5. A new gene encoding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
6. A cyclophilin B gene encodes antigenic epitopes recognized by HLA-A24-restricted and tumor specific CTLs
7. A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases
8. lck
9. A tyrosine kinase profile of prostate carcinoma
10. lck from type I promoter transcripts in colon carcinoma
11. Lck associates with and is activated by Kit in a small cell lung cancer cell line: Inhibition of SCF-mediated growth by the Src family kinase inhibitor PP1
12. Over-expression and activation of the tyrosine kinase Src in human pancreatic carcinoma
13. lck)
14. Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes
15. Two lck transcripts containing different 5′ untranslated regions are present in T cells
16. Differential expression of two classes of lck transcripts upon phorbol ester treatment of human leukemic T cells
17. Identification of a SART1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes
18. Differential immune reactivity of tumour-intrinsic and peripheral blood lymphocytes against autoplastic colorectal carcinoma cells
19. Specific and non-specific lymphocyte cytotoxicity in colon carcinoma
20. Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site
21. Genetics of src: Structure and functional organization of a protein tyrosine kinase
22. Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
23. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups