Fast, simple and cost-effective determination of thiopental in human plasma by a new HPLC technique

Clinica Chimica Acta

Volumn 305, Issue 1-2, 2001, Pages 41-45

  Coppa, Gilberto ^a   Testa, Roberto ^b   Gambini, Anna Margarucci ^a   Testa, Ivano ^c   Tocchini, Massimo ^a   Bonfigli, Anna Rita ^b  

^a General Hospital   (Italy)

^b INRCA   (Italy)

^c UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Anaesthesia; Barbiturate; HPLC; Thiopental

Indexed keywords

ACETONITRILE; BARBITURIC ACID DERIVATIVE; ETHYLENE GLYCOL; METHANOL; PLASMA PROTEIN; THIOPENTAL; TRICHLOROACETIC ACID; WATER; ZINC SULFATE;

ACCURACY; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; CALIBRATION; CENTRIFUGATION; COST EFFECTIVENESS ANALYSIS; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; PROTEIN DENATURATION; RELIABILITY;

ANESTHETICS, INTRAVENOUS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COST-BENEFIT ANALYSIS; HUMANS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; THIOPENTAL;

EID: 0035105145     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-8981(00)00417-4     Document Type: Article

References (15)

1. Pharmacodynamics and pharmacokinetics of thiopental
2. Thiopental attenuates energic impairment but fails to normalize cerebrovascular fluid glutamate in brain-injured patients
3. Protective effect of thiopental against cerebral ischemia during circulatory effect
4. Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: A meta-analysis
5. Thiopental pharmacokinetics under conditions of long-term infusion
6. Time dependent pharmacokinetics of high dose thiopental infusion in intensive care patients
7. Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section
8. Brain-stem, monitoring. II. Preterminal BAEP changes observed until brain death in deeply comatose patients
9. Simple, rapid and sensitive reversed-phase high performance liquid chromatographic method for thiopental and pentobarbital determination in plasma and brain tissue
10. Determination of thiopental measured in human blood by reversed-phase high performance liquid chromatography
11. Micromethod for determination of thiopental in human plasma by high performance liquid chomatography
12. Determination of thiopental and pentobarbital in plasma using high performance liquid chromatography
13. High-performance liquid chromatographic assay for thiopental in human plasma. Application to pharmacokinetic studies
14. Determination of plasma metformin by a new cation-exchange HPLC technique
15. High-performance liquid chromatographic determination of thiopentone enantiomers in sheep plasma