Cyclic AMP is a key messenger in the regulation of skin pigmentation;L'AMP cyclique est un régulateur de la pigmentation de la peau

Medecine/Sciences

Volumn 17, Issue 2, 2001, Pages 177-185

  Bertolotto, C ^a   Busca, R ^a   Ballotti, R ^a   Ortonne, J P ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INTERMEDIN DERIVATIVE; MELANIN; MELANOCORTIN 1 RECEPTOR; PHOSPHATIDYLINOSITOL KINASE;

CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME REGULATION; HUMAN; MELANOCYTE; MELANOGENESIS; PROMOTER REGION; REVIEW; SIGNAL TRANSDUCTION; SKIN PIGMENTATION;

EID: 0035104527     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.4267/10608/1890     Document Type: Review

References (47)

1. Biochemical control of melanogenesis and melanosomal organization
2. Phaeomolanin versus eumelanin as a chemical indicator of ultraviolet sensitivity in fair-skinned subjects at high risk for melanoma: A pilot study
3. Genetics of pigmentation: From fancy genes to complex traits
4. Characterization of genes modulated during pheomelanogenesis using differential display
5. The mouse mahogany locus encodes a transmembrane form of human attractin
6. Does alpha-MSH have a role in regulating skin pigmentation in humans
7. Characterization of corticotropin-releasing hormone (CRH) in human skin
8. A case of skin hyperpigmentation due to α-MSH hypersecretion
9. Variants of the melanocyte-stimulating, hormone receptor gene are associated with red hair and fair skin in humans
10. The Asp84Glu variants of the melanocortin 1 receptor (MC1R) is associated with melanoma
11. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
12. Melanocyte-stimulating hormone: A regulator of human melanocyte physiology
13. Regulation of tyrosinase gene expression by cAMP in B16 melanoma cells involves two CATGTG motifs surrounding the TATA box: Implication of the microphthalmia gene product
14. Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: Pivotal role of M boxes (GTCATGTGCT) and of microphthalmia
15. Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein
16. A helix-loop-helix protein related to the immunoglobulin E-box binding protein
17. Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes
18. Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein
19. The POU domain transcription factor Brn-2: Elevated expression in malignant melanoma and regulation of melanocyte-specific gene expression
20. Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter
21. Pax3 and regulation of the melanocyte-specific tyrosinase-related protein-1 promoter
22. TFE3 and TFEB as transcriptional activators of tyrosinase and TRP1 genes
23. Structural organization of the human microphthalmia-associated transcription factor gene containing four alternative promoters
24. Waardenburg's syndrome patients have mutation in the human homologue of the pax-3 paired box gene
25. Epistatic relationship between Waardenburg syndrome genes MITF and PAX3
26. SOX 10 mutations in patients with Waardenburg-Hirschsprung disease
27. Regulation of MITF gene expression by SOX10
28. Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway
29. Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a
30. S6-kinase pathway induces B16 melanoma cell differentiation
31. Inhibition of Rho is required for cAMP-induced melanoma cell differentiation
32. Mitogen-activated protein kinase pathway and AP-1 are activated during cAMP-induced melanogenesis in B-16 melanoma cells
33. Ras mediates the cAMP-dependent activation of extracellular signal regulated kinasees (ERKs) in melanomyte cells
34. In B16 melanoma cells, the inhibition of melanogenesis by TPA results from PKC activation and diminution of microphthalmia binding to the M-box of the tyrosinase promoter
35. Protein kinase C-beta activates tyrosinase by phosphorylating serine residues in its cytoplasmic domain
36. Deletion of the c-kit proto-oncogene in human developmental defect piebald trait
37. MAPK links microphthalmia to c-kit signaling in melanocytes
38. D. lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia
39. Inhibition of the mitogen-activated protein kinase pathway triggers B16 melanoma cells differentiation
40. Regulation of microphthalmia-associated transcription factor MITF protein levels by association with the human ubiquitin-conjugating enzyme hUBC9
41. Ultraviolet B radiation acts through the nitric oxide and cGMP signal transduction pathway to stimulate melanogenesis in human melanocytes
42. Nitric oxide produced by ultraviolet-irradiated keratinocytes stimulates melanogenesis
43. Mechanisms of ultraviolet light-induced pigmentation
44. Ultraviolet B and melanocyte-stimulating hormone (MSH) stimulate mRNA production for alpha MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes
45. Molecular cascades in UV-induced melanogenesis: A central role for melanotropins?
46. Activation of the cyclic AMP pathway by α-melanotropin mediates the response of human melanocytes to ultraviolet B radiation
47. UVB control of melanogenesis via regulation of neutral endopeptidase (NEP), the enzyme responsible for the degradation of alpha-MSH