Ethylnitrosourea-induced mutation in mice leads to the expression of a novel protein in the eye and to dominant cataracts

Genetics

Volumn 157, Issue 3, 2001, Pages 1313-1320

  Graw, Jochen ^a   Klopp, Norman ^a   Löster, Jana ^a   Soewarto, Dian ^b   Fuchs, Helmut ^b   Becker Follmann, Johannes ^c   Reis, André ^c,e   Wolf, Eckhard ^d   Balling, Rudi ^a   Hrabé De Angelis, Martin ^b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b Institute of Developmental Genetics   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AEY1 PROTEIN; BETA CRYSTALLIN; DNA; ETHYLNITROSOUREA; GAMMA CRYSTALLIN; LENS PROTEIN; POLYCLONAL ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CHROMOSOME 1; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE CLUSTER; GENE MUTATION; GENETIC ANALYSIS; LENS NUCLEUS; MALE; MARKER GENE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OPEN READING FRAME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RESTRICTION SITE; START CODON; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CATARACT; CODON; CROSSES, GENETIC; CRYSTALLINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EYE; FEMALE; GENETIC MARKERS; HAPLOTYPES; LENS, CRYSTALLINE; MALE; MICE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUTAGENS; MUTATION; OPEN READING FRAMES; POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, NUCLEIC ACID; SOFTWARE;

ANIMALIA;

EID: 0035103787     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. A frameshift mutation in the γE-crystallin gene of the Elo mouse
2. Two closely linked Drosophila POU domain genes are expressed in neuroblasts and sensory elements
3. Induction of gene mutations in mice: The multiple endpoint approach
4. GOR secondary structure prediction method version IV
5. The crystallins: Genes, proteins, and diseases
6. Cataract mutations and lens development
7. Genetical and biochemical studies of a dominant cataract mutant in mice
8. Characterization of Cat-2′, a radiation-induced dominant cataract in mice
9. Histological and biochemical characterization of the murine cataract mutant Nop
10. Mutation in the βA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse
11. βB2-crystallin in the mammalian retina
12. The γ-crystallins and human cataracts: A puzzle made clearer
13. Large scale ENU screens in the mouse: Genetics meets genomics
14. Genome-wide, large-scale production of mutant mice by ENU mutagenesis
15. Identification of the human βA2-crystallin gene (CRYBA2): Localization of the gene on human chromosome 12 and of the homologous gene on mouse chromosome 1
16. Retinal expression of γ-crystallins in the mouse
17. Three murine cataract mutants (Cat2) are defective in different γ-crystallin genes
18. Link between a novel human γD-crystallin allele and a unique cataract phenotype explained by protein crystallography
19. A simple method for displaying the hydropathic character of a protein
20. Untersuchungen der Proteinsubstanzen in den lichtbrechenden Medien des Auges
21. Expression of βB2-crystallin mRNA and protein in retina, brain and testis
22. Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution
23. A 5-base insertion in the γC-crystallin gene is associated with autosomal dominant variable zonular pulverulent cataract
24. Linkage of polymorphic congenital cataract to the γ-crystallin gene locus on human chromosome 2q33-35
25. Structure of the crystallins
26. Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract
27. Progressive juvenile-onset punctate cataracts caused by mutation of the γD-crystallin gene
28. Lens crystallins: The evolution and expression of proteins for a highly specialized tissue