Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin

Journal of Clinical Psychopharmacology

Volumn 21, Issue 2, 2001, Pages 167-174

  Härtter, Sebastian ^a   Wang, Ximing ^b   Weigmann, Harald ^a   Friedberg, Thomas ^c   Arand, Michael ^a   Oesch, Franz ^a   Hiemke, Christoph ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

6 HYDROXYMELATONIN; ANTIDEPRESSANT AGENT; CITALOPRAM; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; DESIPRAMINE; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; MELATONIN; N ACETYLSEROTONIN; PAROXETINE; RECOMBINANT ENZYME; SEROTONIN UPTAKE INHIBITOR;

ARTICLE; BIOTRANSFORMATION; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; LIVER MICROSOME; METABOLIC INHIBITION; NONHUMAN; PINEAL BODY; PRIORITY JOURNAL;

ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CYTOCHROME P-450 CYP1A2; ENZYME INHIBITORS; FLUVOXAMINE; HUMANS; MELATONIN; MICROSOMES, LIVER; SEROTONIN; THEOPHYLLINE;

EID: 0035103242     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-200104000-00008     Document Type: Article

References (36)

1. Melatonin - The hormone of darkness
2. Introduction: Melatonin in humans
3. Melatonin production: Proteasomal proteolysis in serotonin N-acetyltransferase regulation
4. The mystery of Alzheimer's disease and its prevention by melatonin
5. Plasma melatonin in patients with breast cancer
6. Immunomodulatory role of melatonin: Specific binding sites in human and rodent lymphoid cells
7. Patterns of melatonin rhythms in depression
8. A comparison of melatonin secretion in depressed patients and normal subjects
9. Melatonin levels are reduced in the pineal glands of suicide victims
10. The influence of acute and subchronic administration of various antidepressants on early morning melatonin plasma levels in healthy subjects: Increases following fluvoxamine
11. Nocturnal plasma melatonin concentrations in healthy volunteers: Effect of single doses of dfenfluramine, paroxetine, and ipsapirone
12. Comparison of the effects of acute fluvoxamine and desipramine administration on melatonin and cortisol production in humans
13. The acute and chronic effects of (+) and (-) oxaprotiline upon melatonin secretion in normal subjects
14. Effect of fluoxetine on melatonin in patients with seasonal affective disorder and matched controls
15. Melatonin and cortisol increase after fluvoxamine
16. Melatonin secretion during fluvoxamine treatment in medicated chronic schizophrenic patients: Evidence for the development of tolerance to selective serotonin re-uptake inhibitor
17. Fluvoxamine is a potent inhibitor of CYP1A2
18. Fluvoxamine inhibits the CYP2C19-catalyzed bioactivation of chloroguanide
19. Increased bioavailability of oral melatonin after fluvoxamine coadministration
20. The isolation, purification, and characterization of the principal urinary metabolites of melatonin
21. Involvement of cytochrome P-450 isozymes in melatonin metabolism and clinical implications
22. Non-competitive inhibition of clomipramine N-demethylation by fluvoxamine
23. A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: Expression of CYP3A4, CYP2A6, and CYP2E1
24. Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: An intralaboratory comparison
25. The carbon monoxide-binding pigment of liver microsomes
26. Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principal of protein-dye binding
27. Plasma 6-hydroxymelatonin, 6-sulfatoxymelatonin and melatonin kinetics after melatonin administration to rats
28. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals; studies with liver microsomes of 30 Japanese and 30 Caucasians
29. A graphic method for the determination and presentation of binding parameters in a complex system
30. Inhibitors of imipramine metabolism by human liver microsomes
31. Selective serotonin reuptake inhibitors and theophylline metabolism in human liver microsomes: Potent inhibition by fluvoxamine
32. Nonlinear pharmacokinetics of fluvoxamine and gender differences
33. Differential effects of fluvoxamine and paroxetine on the nocturnal secretion of melatonin
34. Fluvoxamine strongly inhibits melatonin metabolism in a patient with low-amplitude melatonin profile
35. Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications
36. Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes