Impaired protective immunity and T helper 2 responses in alymphoplasia (aly) mutant mice infected with Trichinella spiralis

Immunology

Volumn 102, Issue 2, 2001, Pages 218-224

  Korenaga, M ^a   Akimaru, Y ^a   Shamsuzzaman, S M ^a   Hashiguchi, Y ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 3; INTERLEUKIN 4; MONOCLONAL ANTIBODY CD3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CELL COUNT; CELLULAR IMMUNITY; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MAST CELL; MOUSE; MOUSE MUTANT; NONHUMAN; PRIORITY JOURNAL; SPLEEN LYMPHOCYTE; TH2 CELL; TRICHINELLA SPIRALIS; WORM EXPULSION;

ANIMALS; CELL CULTURE TECHNIQUES; CELL DIVISION; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTERFERON TYPE II; INTERLEUKIN-4; INTESTINAL MUCOSA; MALE; MAST CELLS; MICE; MICE, MUTANT STRAINS; POINT MUTATION; SPLEEN; TH2 CELLS; TRICHINELLA SPIRALIS; TRICHINOSIS;

EID: 0035103210     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01169.x     Document Type: Article

References (41)

1. Antigen-presenting cells: Epithelial cells
2. A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice
3. Alympholasia is caused by a point mutation in the mouse gene encoding NF-κB-inducing kinase
4. - T-helper cells that are generated in the intestine
5. - cells requires MHC class II compatibility
6. Requirement for two discrete stimuli for induction of the intestinal rapid expulsion response against Trichinella spiralis in rats
7. + cells during the early stages of a Trichinella spiralis infection
8. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
9. Acceleration of IgE responses by treatment with recombinant interleukin-3 prior to infection with Trichinella spiralis in mice
10. Injection of recombinant interleukin 3 hastens worm expulsion in mice infected with Trichinella spiralis
11. IL-4-regulated enteropathy in an intestinal nematode infection
12. Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism
13. Intestinal nematode parasites, cytokines and effector mechanisms
14. The immunopathology of trichiniasis in T-cell deficient mice
15. Intestinal phase of Trichinella spiralis in congenitally athymic (nude) mice
16. Trichinella spiralis infection in congenitally athymic (nude) mice: Parasitological, serological and haematological studies with observations on intestinal pathology
17. Host resistance against Listeria monocytogenes is reciprocal during the course of infection in alymphoplastic aly mutant mice
18. Host protective immunity to Trichinella spiralis in mice: Activation Th cell subsets and lymphokine secretion in mice expressing different phenotypes
19. Influence of resistant and susceptible genotype, IL-1, and lymphoid organ on Trichinella spiralis-induced cytokine secretion
20. Gut-associated lymphoid tissue: Antigen handling and T-lymphocyte responses
21. Mucosal immune responses, an overview
22. Migration of lymphoblasts to the small intestine: III. Strain differences and relationship to distribution and duration of Trichinella spiralis infection
23. Short lived, dividing cells mediate adoptive transfer of immunity to Trichinella spiralis in mice: I. Availability of cells in primary and secondary infections in relation to cellular changes in the mesenteric lymph node
24. L3T4-positive T lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice
25. Characterization of a cell population in thoracic duct lymph that adoptively transfers rejection of adult Trichinella spiralis to normal rats
26. Early induction and augmentation of parasitic antigen-specific antibody-producing B lymphocytes in the non-Peyer's patch region of the small intestine
27. Alternate mucosal immune system: Organized Peyer's patches are not required for IgA responses in the gastrointestinal tract
28. Production of proinflammatory cytokines and inflammatory mediators in human intestinal epithelial cells after invasion by Trichinella spiralis
29. Distinct roles in lymphoid organogenesis for lymphotoxins α and β revealed in lymphotoxin β-deficient mice
30. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin
31. Lymphotoxin-α-deficient mice: Effects on secondary lymphoid organ development and humoral immune responsiveness
32. Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor
33. Tumor necrosis factor α is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection
34. Antibodies to IL-3 and IL-4 suppress helminth-induced intestinal mastocytosis
35. v mice
36. v mice
37. V mice reconstituted with haematopoietic and lymphopoietic cells and origin of mucosal mast cells
38. The in vivo role of stem cell factor (c-kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice
39. A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth
40. Distribution of intestinal mast cell proteinase in blood and tissues of normal and Trichinella-infected mice
41. Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice