Detection of single-base DNA mutations by enzyme-amplified electronic transduction

Nature Biotechnology

Volumn 19, Issue 3, 2001, Pages 253-257

  Patolsky, F ^a   Lichtenstein, A ^a   Willner, I ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AVIDIN; DNA; DOUBLE STRANDED DNA; OLIGONUCLEOTIDE;

ARTICLE; GENE MUTATION; GENE TARGETING; GENETIC PROCEDURES; PIEZOELECTRICITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SIGNAL TRANSDUCTION; SPECTROSCOPY; STRUCTURAL GENE; TRANSDUCER;

ALKALINE PHOSPHATASE; AVIDIN; BASE SEQUENCE; BIOTINYLATION; CALIBRATION; DNA MUTATIONAL ANALYSIS; DNA-DIRECTED DNA POLYMERASE; ELECTRIC CONDUCTIVITY; ELECTRIC IMPEDANCE; ELECTRODES; ENZYMES; HUMANS; OLIGONUCLEOTIDE PROBES; POINT MUTATION; POLYMORPHISM, GENETIC; PRECIPITATION; QUARTZ; SENSITIVITY AND SPECIFICITY; SOLUBILITY; TAY-SACHS DISEASE;

EID: 0035100142     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/85704     Document Type: Article

References (25)

1. Direct allelic variation scanning of the yeast genome
2. Mutation detection by electrocatalysis at DNA-modified electrodes
3. Electrochemical biosensors for DNA sequence detection
4. Electrochemical studies of the interaction of metal chelates with DNA. 4. Voltammetric and electrogenerated chemiluminescent studies of the interaction of tris(2,2′-bipyridine)osmium(II) with DNA
5. Molecular computation of solutions to combinatorial problems
6. DNA computing on surfaces: Encoding information at the single base level
7. Enzymatic ligation reactions of DNA 'words' on surfaces for DNA computing
8. Surface plasmon resonance imaging measurements of DNA hybridization adsorption and streptavidin/DNA multilayer formation at chemically modified gold surfaces
9. Towards bioelectronics: Specific DNA recognition based on an oligonucleotide- functionalized polypyrrole
10. Voltammetric DNA biosensor for cystic-fibrosis based on a modified carbon-paste electrode
11. Sequence-specific gene detection with a gold electrode modified with DNA probes and an electrochemically active dye
12. Sensing and amplification of oligonucleotide-DNA interactions by means of impedance spectroscopy: A route to a Tay-Sachs sensor
13. Peptide nucleic acid probes for sequence-specific DNA biosensors
14. Amplified microgravimetric quartz crystal microbalance analysis of oligonucleotide complexes: A route to Tay-Sachs biosensor device
15. Enzyme amplified amperometric detection of hybridization and of a single base pair mutation in an 18-base oligonucleotide on a 7-μm diameter microelectrode
16. Cellular oncogenes and multistep carcinogenesis
17. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras
18. K-ras mutations in duodenal aspirate without seretin stimulation for screening of pancreatic and biliary tract carcinoma
19. Precipitation of an insoluble product on enzyme monolayer electrodes for biosensor applications: Characterization by Faradaic Impedance spectroscopy, cyclic voltammetry and microgravimetric quartz crystal microbalance analyses
20. Enzyme linked amplified electrochemical sensing of oligonucleotide-DNA interactions by means of precipitation of an insoluble product and using impedance spectroscopy
21. Electrochemical quantification of DNA immobilized on gold
22. DNA variation and the future of human genetics
23. Characterization of single-nucleotide polymorphisms in coding regions of human genes
24. 2 gangliosides
25. The major defect in Ashkenazi Jews with Tay-Sachs disease is an inversion in the gene for the (α-chain of β-hexosaminidase