The codon 17 polymorphism of the CTLA4 gene in type 2 diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 2, 2001, Pages 653-655

  Rau, Harald ^a   Braun, Jens ^a   Donner, Horst ^a   Seissler, Jochen ^a   Siegmund, Thorsten ^a   Usadel, Klaus H ^a   Badenhoop, Klaus ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

ADULT; AGE DISTRIBUTION; AGED; ALLELE; ARTICLE; BODY MASS; CAUCASIAN; CONTROLLED STUDY; EXON; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HYPERTENSION; INSULIN TREATMENT; MAJOR CLINICAL STUDY; MALE; MICROANGIOPATHY; NON INSULIN DEPENDENT DIABETES MELLITUS; PARAMETER; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SINGLE STRAND CONFORMATION POLYMORPHISM; SYMPTOM;

AMINO ACID SUBSTITUTION; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; C-PEPTIDE; CODON; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIABETIC NEPHROPATHIES; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GERMANY; HLA-DQ ANTIGENS; HUMANS; IMMUNOCONJUGATES; IMMUNOGLOBULIN FC FRAGMENTS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; REFERENCE VALUES;

EID: 0035098317     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.2.653     Document Type: Article

References (13)

1. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
2. CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
3. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
4. CTLA4 gene polymorphism cor-relates with the mode of onset and presence of ICA512 Ab in Japanese type 1 diabetes
5. Association of CTLA4 gene A-G polymorphism with type 1 diabetes in Chinese children
6. IDDM12 (CTLA4) on 2q33 and IDDM13 on 2q34 in genetic susceptibility to type 1 diabetes (insulin-dependent)
7. Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33
8. Costimulatory B7 molecules in the pathogenesis of infectious and autoimmune diseases
9. CTLA4 mediates antigen-specific apoptosis of human T cells
10. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease
11. CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location
12. Susceptibility and resistance alleles of HLA DQA1 and HLA DQB1 are shared in endocrine autoimmune disease
13. CTLA-4 gene polymorphism associated with Graves' disease in a caucasian population