Complement C3b interactions studied with surface plasmon resonance technique

International Immunopharmacology

Volumn 1, Issue 3, 2001, Pages 495-506

  Jokiranta, T Sakari ^a,b   Westin, Jerker ^c   Nilsson, Ulf R ^c   Nilsson, Bo ^c   Hellwage, Jens ^b   Löfås, Stefan ^d   Gordon, David L ^a   Ekdahl, Kristina Nilsson ^c   Meri, Seppo ^b  

^a FLINDERS MEDICAL CENTRE   (Australia)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^d BIACORE AB   (Sweden)

Author keywords

C3b; C5; CD35; Factor B; Factor H; Surface plasmon resonance

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CARBOXYMETHYLDEXTRAN; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT COMPONENT C5; COMPLEMENT FACTOR H; COMPLEMENT RECEPTOR; LIGAND; POLYSTYRENE;

BINDING SITE; BIOSENSOR; COMPLEMENT ALTERNATIVE PATHWAY; COMPLEMENT DEPOSITION; COMPLEMENT FIXATION; COMPLEMENT SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DATA ANALYSIS; HALF LIFE TIME; HUMAN; LIGAND BINDING; PRIORITY JOURNAL; PRODUCTIVITY; SURFACE PLASMON RESONANCE;

BINDING SITES; COMPLEMENT C3B; COMPLEMENT C3C; COMPLEMENT C3D; COMPLEMENT C5; COMPLEMENT FACTOR B; COMPLEMENT FACTOR H; COMPLEMENT PATHWAY, ALTERNATIVE; DEXTRANS; HUMANS; LIGANDS; POLYSTYRENES; RECEPTORS, COMPLEMENT 3B; SURFACE PLASMON RESONANCE; SURFACE PROPERTIES;

EID: 0035096383     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1567-5769(00)00042-4     Document Type: Conference Paper

References (37)

1. C3 proactivator convertase and its mode of action
2. Complement C3 convertase: Cell surface restriction of b1H control and generation of restriction on neuraminidase-treated cells
3. Control of the amplification convertase of complement by the plasma protein β1H
4. The alternative pathway of complement activation: The role of C3 and its inactivator (KAF)
5. Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3
6. Covalent binding and hemolytic activity of complement proteins
7. The covalent-binding reaction of complement component C3
8. The role of properdin in the alternate pathway of complement activation
9. Assembly of the cytolytic alternative pathway of complement from 11 isolated plasma proteins
10. Biosensors in immunology: The story so far
11. Experimental design for kinetic analysis of protein-protein interactions with surface plasmon resonance biosensors
12. Direct and competitive kinetic analysis of the interaction between human IgG1 and a one domain analogue of protein A
13. Methods for site controlled coupling to carboxymethyldextran surfaces in surface plasmon resonance sensors
14. Each of the three binding sites on factor H interacts with a distinct site on C3b
15. Purification of human complement factor D from the peritoneal fluid of patients on chronic ambulatory peritoneal dialysis
16. Large scale isolation of functionally active components of the human complement system
17. Common binding region of complement factors B, H and CR1 on C3b revealed by monoclonal anti-C3d
18. Isolation and characterization of a 33,000-dalton fragment of complement Factor B with catalytic and C3b binding activity
19. Activation of the alternative pathway of complement by monoclonal l light chains in membranoproliferative glomerulonephritis
20. Localization of the heparin-binding site on complement factor H
21. Pattern of degradation of human complement fragment, C3b
22. A fluorimetric assay for native C3, the hemolytically active form of the third component of human complement
23. Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors
24. C3 convertase of human complement: Enhanced formation and stability of the enzyme generated with nickel instead of magnesium
25. An optical biosensor system for molecular interaction studies
26. Regulation of complement activation by C-reactive protein: Targeting the complement inhibitory activity of factor H by an interaction with short consensus repeat domains 7 and 8-11
27. Interaction of the complement proteins C2 and C4
28. Inhibition of complement activation by a new synthetic peptide specific for complement component C3: Its inhibitory effect on complement activation and complement-mediated functions under conditions resembling those in an extracorporeal circuit
29. Interaction of Vaccinia virus complement control protein with human complement proteins: Factor I-mediated degradation of C3b to iC3b1 inactivates the alternative complement pathway
30. Functional properties of complement factor H-related proteins FHR-3 and FHR-4: Binding to the C3d region of C3b and differential regulation by heparin
31. Nephritogenic λ light-chain dimer - A unique human mini autoantibody against complement factor H
32. Specificity of the thioester-containing reactive site of human C3 and its significance to complement activation
33. The structure and function of the third component of human complement: I. The nature and extent of conformational changes accompanying C3 activation
34. Production of mouse monoclonal antibodies that detect distinct neoantigenic epitopes on bound C3b and iC3b but not on the corresponding soluble fragments
35. Dissection of CR1, factor H, membrane cofactor protein, and factor B binding and functional sites in the third complement component
36. The binding of human complement proteins C5, factor B, b1H and properdin to complement fragment C3b on zymosan
37. A new function of the activated third component of complement: Binding to C5, an essential step for C5 activation