Is there a need for blood substitutes in the new millennium and what should we expect in the way of safety and efficacy? A research perspective

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

Volumn 29, Issue 1, 2001, Pages 1-3

  Alayash, A I ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD SUBSTITUTE; CATALASE; CYSTEINE; FREE RADICAL; HEME; HEMOGLOBIN; HYDROGEN PEROXIDE; LIPID PEROXIDE; NITRIC OXIDE; OXYGEN RADICAL; PEROXYNITRITE; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; BINDING AFFINITY; BLOOD FLOW; BLOOD SUBSTITUTION; CELL FREE SYSTEM; CLINICAL RESEARCH; HYPERTENSION; MOLECULAR SIZE; REVIEW; SITE DIRECTED MUTAGENESIS; SMOOTH MUSCLE CONTRACTION; VASCULAR ENDOTHELIUM;

BLOOD SUBSTITUTES; CONSUMER PRODUCT SAFETY; FORECASTING; HEALTH SERVICES NEEDS AND DEMAND; HEMOGLOBINS; HUMANS; HYPERTENSION; NITRIC OXIDE;

EID: 0035093203     PISSN: 10731199     EISSN: None     Source Type: Journal    
DOI: 10.1081/BIO-100001251     Document Type: Review

References (13)

1. Editorial: Is there a need for blood substitutes in the new millennium and what can we expect in way of safety and efficacy?
2. Editorial. NO, the molecule of the year
3. Pharmacology of hemoglobin therapeutics
4. Hemoglobin-based blood substitutes: Oxygen carriers, pressor agents or oxidants?
5. Diffusion-limited reaction of free nitric oxide with eyrthrocytes
6. Intravacular flow decreases erthyocyte consumption of nitric oxide
7. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin
8. Glutaraldehyde modification of recombinant human hemoglobin alters its hemodynamic properties
9. Redox reactions of hemoglobin and myoglobin: Biological and toxicological implications
10. Pyridoxalated hemoglobin polyoxyethylene: A nitric oxide scavenger with antioxidant activity for the treatment of nitric oxide-induced shock
11. Polyhemoglobin-superoxide dismutase-catalase as a blood substitute with antioxidant properties
12. S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control
13. Blood substitutes