Attenuation of hypertension and heart hypertrophy by adeno-associated virus delivering angiotensinogen antisense

Hypertension

Volumn 37, Issue 2 II, 2001, Pages 376-380

  Kimura, Birgitta ^a   Mohuczy, Dagmara ^a   Tang, Xiaoping ^a   Ian Phillips, M ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Adeno associated virus; Angiotensinogen; Antisense; Gene therapy; Hypertrophy, cardiac

Indexed keywords

ANGIOTENSINOGEN; ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY RNA; PLASMID VECTOR; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ATTENUATION; CONFERENCE PAPER; CONTROLLED STUDY; GENE THERAPY; HEART HYPERTROPHY; HEART LEFT VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; VIRUS RECOMBINANT;

EID: 0035093075     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.hyp.37.2.376     Document Type: Conference Paper

References (14)

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4. Losartan versus gene therapy: Chronic control of high blood pressure in spontaneously hypertensive rats
5. Antisense inhibition and adeno-associated viral vector delivery for reducing hypertension
6. Intravenous angiotensinogen antisense in AAV-based vector decreases hypertension
7. Antisense inhibition of hypertension in the spontaneously hypertensive rat
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12. Expression of GFRalpha-1, receptor for GDNF, in rat brain capillary during postnatal development of the BBB
13. Transient inhibition of angiotensinogen production in transgenic mice bearing an antisense angiotensinogen gene
14. Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy