Formation of a defluorinated metabolite of a quinoxaline antiviral drug catalysed by human cytochrome P450 1A2

Journal of Pharmacy and Pharmacology

Volumn 53, Issue 3, 2001, Pages 403-408

  Mutch, P J ^a   Dear, G J ^a   Ismail, I M ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 7 FLUORO 1,2,3,4 TETRAHYDRO 3 OXO 1 QUINOXALINECARBOXYLIC ACID ISOPROPYL ESTER; ANTIVIRUS AGENT; AROMATIC COMPOUND; CYTOCHROME P450; CYTOCHROME P450 1A2; DRUG METABOLITE; FLUORINE; HYDROXYL GROUP; QUINOXALINE DERIVATIVE;

ARTICLE; BIOTRANSFORMATION; CATALYSIS; DEFLUORINATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; INCUBATION TIME; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN EXPRESSION; RADIOCHROMATOGRAPHY; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; ANTIVIRAL AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP1A2; HALF-LIFE; HUMANS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROSOMES, LIVER; QUINOXALINES;

EID: 0035093016     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357011775479     Document Type: Article

References (12)

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7. GW420867X, a new non-nucleoside reverse transcriptase inhibitor (NNRTI), single and repeat dose pharmacokinetics (PK)
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9. 19F-NMR spectroscopy and directly coupled HPLC-NMR-MS
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