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Volumn 66, Issue 4, 2001, Pages 245-251
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Pharmacodynamics and pharmacokinetics of single doses of subcutaneous pegylated human G-CSF mutant (Ro 25-8315) in healthy volunteers: Comparison with single and multiple daily doses of Filgrastim
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Author keywords
G CSF; Mutant; Pegylation; Pharmacodynamics; Pharmacokinetics
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Indexed keywords
CD34 ANTIGEN;
GRANULOCYTE COLONY STIMULATING FACTOR;
MACROGOL;
MUTANT PROTEIN;
PARACETAMOL;
RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;
RO 25 8315;
UNCLASSIFIED DRUG;
ADULT;
AREA UNDER THE CURVE;
ARTICLE;
BACKACHE;
BIOLOGICAL THERAPY;
BONE PAIN;
CELL COUNT;
CELL SUBPOPULATION;
CLINICAL TRIAL;
COLONY FORMING UNIT GM;
CONJUGATION;
CONTROLLED CLINICAL TRIAL;
CONTROLLED STUDY;
DOSE RESPONSE;
DOUBLE BLIND PROCEDURE;
DRUG BLOOD LEVEL;
DRUG EFFECT;
DRUG HALF LIFE;
DRUG TOLERABILITY;
HEADACHE;
HUMAN;
MALE;
NEUTROPHIL;
NORMAL HUMAN;
PRIORITY JOURNAL;
RANDOMIZED CONTROLLED TRIAL;
THROMBOCYTOPENIA;
ADULT;
AREA UNDER CURVE;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DOUBLE-BLIND METHOD;
DRUG ADMINISTRATION SCHEDULE;
FILGRASTIM;
GRANULOCYTE COLONY STIMULATING FACTOR, RECOMBINANT;
HEADACHE;
HEMATOPOIETIC STEM CELL MOBILIZATION;
HEMATOPOIETIC STEM CELLS;
HUMANS;
INJECTIONS, SUBCUTANEOUS;
LEUKOCYTE COUNT;
LYMPHOCYTE COUNT;
MALE;
MIDDLE AGED;
NEUTROPHILS;
PAIN;
POLYETHYLENE GLYCOLS;
SAFETY;
THROMBOCYTOPENIA;
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EID: 0035092723
PISSN: 03618609
EISSN: None
Source Type: Journal
DOI: 10.1002/ajh.1052 Document Type: Article |
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Times cited : (71)
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References (18)
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