An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 1, 1997, Pages 358-365

  Vernhet, Laurent ^a   Petit, Jean Yves ^a   Lang, François ^a,b,c  

^a UNIVERSITÉ DE NANTES   (France)

^b INSERM   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; BENZAMIDE DERIVATIVE; BISINDOLYLMALEIMIDE; CALCIMYCIN; CALCIUM IONOPHORE; ENDOTOXIN; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL DIBUTYRATE; PHORBOL ESTER; PHOSPHOLIPASE A2; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; TUMOR NECROSIS FACTOR; ZYMOSAN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONIC ACID; BENZAMIDES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DIGLYCERIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALEIMIDES; MITOGEN-ACTIVATED PROTEIN KINASE 1; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030799006     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. BADGER, A. M., BRADBEER, J. N., VOTTA, B., LEE, J. C., ADAMS, J. L. AND GRISWOLD, D. E.: Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Pharmacol. Exp. Ther. 279: 1453-1461, 1996.
2. BASU, A.: The potential of protein kinase C as a target for anticancer treatment. Pharmac. Ther. 59: 257-280, 1993.
3. BOKEMEYER, D., SOROKIN, A. AND DUNN, M. J.: Multiple intracellular MAP kinase signaling cascades. Kidney Int. 49: 1187-1198, 1996.
4. DONG, Z., QI, X. AND FIDLER, I. J.: Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products. J. Exp. Med. 177: 1071-1077, 1993.
5. 2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan. J. Infect. Dis. 174: 777-785, 1996.
6. ESPEVIK, T. AND NISSEN-MEVER, J.: A highly sensitive cell line, WEHI164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. J. Immunol. Meth. 95: 99-105, 1986.
7. GENG, Y., ZHAN, B. AND LOTZ, M.: Protein tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes. J. Immunol. 151: 6692-6700, 1993.
8. GUPTA, D., JIN, Y-P. AND DZIARSKI, R.: Peptidoglycan induces transcription and secretion of TNF-α and activation of Lyn, extracellular signal-regulated kinase, and Rsk signal transduction proteins in mouse macrophages. J Immunol. 155: 2620-2630, 1995.
9. HAMBLETON, J., MCMAHON, M. AND DEFRANCO, A. L.: Activation of raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J. Exp. Med. 182: 147-154, 1995.
10. HUG, H. AND SARRE, T. F.: Protein kinase C isoenzymes: Divergence in signal transduction? Biochem. J. 291: 329-343, 1993.
11. HUWILER, A. AND PFEILSCHIFTER, J.: A role for protein kinase C-α in zymosan-stimulated eicosanoid synthesis in mouse peritoneal macrophages. Eur. J. Biochem. 217: 69-75, 1993.
12. KAMBAYASHI, T., JACOB, C. O., ZHOU, D., MAZUREK, N., FONG, M. AND STRASSMANN, G.: Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages. J. Immunol. 155: 4909-4916, 1995.
13. KITANO, T., GO, M., KIKKAWA, U. AND NISHIZUKA, Y.: Assay and purification of protein kinase C. Methods Enzymol. 124: 349-352, 1986.
14. KOLCH, W., HELDECKER, G., KOLCHS, G., VAHIDI, H., MISCHAK, H., FINKENZELLER, G., MAEMÉ, D. AND RAPP, U. R.: Protein kinase C-α activates Raf-1 by direct phosphorylation. Nature (Lond.) 364: 249-252, 1993.
15. KOVACS, L. J., RADZIOCH, D., YOUNG, H. A. AND VARESIO, L.: Differential inhibition of IL-1 and TNF-α mRNA expression by agents which block second messenger pathways in murine macrophages. J. Immunol. 141: 3101-3105, 1988.
16. LANG, F., ROBERT, J-M., BOUCROT, P., WELIN, L. AND PETIT, J-Y.: New anti-inflammatory compounds that inhibit tumor necrosis factor production: Probable interaction with protein kinase C. J. Pharmacol. Exp. Ther. 275: 171-176, 1995.
17. LEE, J. C., LAYDON, J. T., MCDONNELL, P. C., GALLAGHER, T. F., KUMAR, S., GREEN, D., MCNULTY, D., BLUMENTHAL, M. J., HEYS, J. R., LANDVATTER, S. W., STRICKLER, J. E., MCLAUGHLIN, M. M., SIEMENS, I. R., FISHER, S. M., LIVI, G. P., WHITE, J. R., ADAMS, J. L. AND YOUNG, P. R.: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature (Lond.) 372:739-746, 1994.
18. LEEVERS, S. L., PATERSON, H. F. AND MARSHALL, C. J.: Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (Lond.) 369: 411-414, 1994.
19. 2 is phosphorylated and activated by MAP kinase. Cell 72: 269-278, 1993.
20. 2 enzymes: Regulation and physiological roles. Biochem. Pharmacol. 48: 1-10, 1994.
21. NISHIZUKA, Y.: The role of protein kinase C in cell surface signal transduction and tumor promotion. Nature (Lond.) 308: 693-698, 1984.
22. NOVOGRODSKY, A., VANICHKIN, A., PATYA, M., GAZIT, A., OSHEROV, N. AND LEVITZKI, . A.: Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science (Wash. DC) 264: 1319-1322, 1994.
23. 2 activation by phosphorylation in mouse peritoneal macrophages. J. Biol. Chem. 268: 24506-24513, 1993.
24. 2. J. Biol. Chem. 269: 19480-19487, 1994.
25. REIMANN, T., BÜSCHER, D., HIPSKIND, R. A., KRAUTWALD, S., LOHMANN-MATTHES, M-L. AND BACCARINI, M.: Lipopolysaccharide induces activation of the Raf-1/ MAP kinase pathway. J. Immunol. 153: 5740-5749, 1994.
26. 2 in rat experimental brain oedema. Pharmacol. Toxicol. 70: 67-69, 1992.
27. ROBERT, J-M. H., ROBERT-PIESSARD, S., COURANT, J., LE BAUT, G., ROBERT, B., LANG, F., PETIT, J-Y., GRIMAUD, N. AND WELIN, L.: Non-carboxylic antiinflammatory compounds. III. N-(4,6-dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors. Eur. J. Med. Chem. 30: 915-924, 1995.
28. SANGHERA, J. S., WEINSTEIN, S. L., ALUWALIA, M., GIRN, J. AND PELECH, S. L.: Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages. J. Immunol. 156: 4457-4465, 1996.
29. SEKIGUCHI, K., TSUKADA, M., OGITA, K., KIKKAWA, U. AND NISHIZUKA, Y.: Three distinct forms of rat brain protein kinase C: Differential response to unsaturated fatty acids. Biochem. Biophys. Res. Commun. 145: 797-802, 1987.
30. SHAPIRA, L., TAKASHIBA, S., CHAMPAGNE, C., AMAR, S. AND VAN DYKE, T. K.: Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-α and IL-1β production by human monocytes. J. Immunol. 153: 1818-1824, 1994.
31. TOULEC, D., PIANETTI, P., COSTE, H., BELLEVERGUE, P., GRAND-PERRET, T., AJAKANE, M., BAUDET, V., BOISSIN, P., BOURSIER, E., LORIOLLE, F., DUHAMEL, L., CHARON, D. AND KIRILOVSKY, J.: The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J. Biol. Chem. 266: 15771-15781, 1991.
32. TSCHAIKOWSKY, K.: Protein kinase C inhibitors suppress LPS-induced TNF production in alveolar macrophages and in whole blood: The role of encapsulation into liposomes. Biochim. Biophys. Acta 1222: 113-121, 1994.
33. VASSALLI, P.: The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10: 411-452, 1992.
34. VERNHET, L., HICHAMI, A., HAMON, L., COCHET, M-F. AND LEGRAND, A. B.: Incorporation of 12(S)-hydroxyeicosatetraenoic acid into phospholipids and active diacylglcerols in rat liver epithelial cells: Effects on DNA synthesis. J. Lipid Med. 13: 233-248, 1996.
35. WARTMANN, M. AND DAVIS, R. J.: The native structure of the activated Raf protein kinase is a membrane bound multi-subunit complexe. J. Biol. Chem. 269: 6695-6701, 1994.
36. WEINSTEIN, S. L., GOLD, M. R. AND DEFRANCO, A. L.: Bacterial lipopolysaccharide stimulates tyrosine phosphorylation in macrophages. Proc. Natl. Acad. Sci. U.S.A. 88: 4148-4152, 1991.
37. WEINSTEIN, S. L., SANGHERA, J. S., LEMKE, K., DEFRANCO, A. AND PELECH, S. L.: Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267: 14955-14962, 1992.
38. YASUDA, I., KISHIMOTO, A., TANAKA, S., TOMINAGA, M., SAKURAI, A. AND NISHIZUKA, Y.: A synthetic peptide substrate for selective assay of protein kinase C. Biochem. Biophys. Res. Commun. 166: 1220-1227, 1990.