Novel non-peptide GPIIb/IIIa antagonists: Synthesis and biological activities of 2-[4-[2-(4-amidinobenzoylamino)-2-(substituted)acetyl]-3-(2-methoxy-2- oxoethyl)-2-oxopiperazinyl] acetic acids

Chemical and Pharmaceutical Bulletin

Volumn 49, Issue 3, 2001, Pages 258-267

  Kitamura, S ^a   Fukushi, H ^a   Miyawaki, T ^a   Kawamura, M ^a   Terashita, Z I ^a   Sugihara, H ^a   Naka, T ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

2 oxopiperazine derivative; 4 methoxyphenylalanine derivative; Antiplatelet effect; GPIIb IIIa antagonist

Indexed keywords

2 [4 [2 (4 AMIDINOBENZOYLAMINO) 2 ACETYL] 3 (2 METHOXY 2 OXOETHYL) 2 OXOPIPERAZINYL]ACETIC ACID; 2 OXOPIPERAZINE DERIVATIVE; 4 (4 AMIDINOBENZOYLGLYCYL) 3 METHOXYCARBONYLMETHYL 2 OXO 1 PIPERAZINEACETIC ACID; 4 METHOXYPHENYLALANINE DERIVATIVE; ADENOSINE DIPHOSPHATE; FIBRINOGEN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; NONHUMAN; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

ACETATES; AMINO ACIDS; ANIMALS; BINDING SITES; FIBRINOGEN; GUINEA PIGS; HUMANS; INDICATORS AND REAGENTS; MACACA FASCICULARIS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; PIPERAZINES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035086871     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.49.258     Document Type: Article

References (28)