Characterization of the CD154-positive and CD40-positive cellular subsets required for pathogenesis in retrovirus-induced murine immunodeficiency

Journal of Virology

Volumn 75, Issue 8, 2001, Pages 3581-3589

  Green, K A ^a   Noelle, R J ^a   Durell, B G ^a   Green, W R ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; MONOCLONAL ANTIBODY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; MALE; MOUSE; MURINE LEUKEMIA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RETROVIRUS; RODENT DISEASE; SYMPTOMATOLOGY; T LYMPHOCYTE SUBPOPULATION; VIRUS PATHOGENESIS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE DELETION; LYMPHOCYTE SUBSETS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; MITOGENS; MURINE ACQUIRED IMMUNODEFICIENCY SYNDROME; RETROVIRIDAE; SPLEEN; TUMOR CELLS, CULTURED;

EID: 0035086252     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.8.3581-3589.2001     Document Type: Article

References (54)

1. CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome
2. Molecular and biological characterization of a murine ligand for CD40
3. Severe immunodeficiency disease induced by a defective murine leukemia virus
4. The SCID mouse mutant: Definition characterization, and potential uses
5. Abrogation of resistance to severe mousepox in C57BL/6 mice infected with LP-BM5 murine leukemia viruses
6. B cells are required for induction of T cell abnormalities in a murine retrovirus-induced immunodeficiency syndrome
7. A defective virus is associated with induction of a murine retrovirus-induced immunodeficiency syndrome, MAIDS
8. + T cell clones can provide B cell help
9. The function of antigen-presenting cells in mice with severe combined immunodeficiency
10. Mice transgenic for a soluble form of murine cytotoxic T lymphocyte antigen 4 are refractory, to murine acquired immune deficiency syndrome development
11. CD28-B7 costimulatory blockade by CTLA4Ig delays the development of retrovirus-induced murine AIDS
12. + T cells
13. CD40/CD40L interactions and cytokines regulate HIV replication in B cells in vitro
14. Antibody to the ligand for CD40 (gp39) inhibits murine AIDS-associated splenomegaly, hypergammaglobulinemia, and immunodeficiency in disease-susceptible C57BL/6 mice
15. Evidence for a continued requirement for CD40/CD40 ligand (CD154) interactions in the progression of LP-BM5 retrovirus-induced murine AIDS
16. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
17. Retrovirus-induced murine acquired immunodeficiency syndrome: Natural history of infection and differing susceptibility of inbred mouse strains
18. + T cell clones allow B cell growth and differentiation
19. Delayed progression of a murine retrovirus-induced acquired immunodeficiency syndrome in X-linked immunodeficient mice
20. The majority of cells infected with the defective murine AIDS virus belong to the B-cell lineage
21. Immunodeficiency and clonal growth of target cells induced by helper-free defective retrovirus
22. Positive selection of TcR alpha beta thymocytes: Is cortical epithelium an obligatory participant in the presentation of major histocompatibility complex protein?
23. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
24. In murine AIDS, B cells are early targets of defective virus and are required for efficient infection and expression of defective virus in T cells and macrophages
25. Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS
26. Characteristics of B cell proliferation and activation in murine AIDS
27. Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosis
28. Characteristics of the cell populations involved in extrathymic lymphosarcoma induced in C57BL/6 mice by RadLV-RS
29. The role of CD40/CD154 interactions in the priming, differentiation, and effector function of helper and cytotoxic T cells
30. Rapid development of murine AIDS is dependent on signals provided by CD54 and CD11a
31. CD40 mediated induction of CD4 and CXCR4 on B lymphocytes correlates with restricted susceptibility to human immunodeficiency virus type 1 infection: Potential role of B lymphocytes as a viral reservoir
32. CD40-CD40 ligand interactions in vivo regulate migration of antigen-bearing dendritic cells from the skin to draining lymph nodes
33. Functional and phenotypic alterations in T cell subsets during the course of MAIDS, a murine retrovirus-induced immunodeficiency syndrome
34. Stat6-deficient mice exhibit normal induction of murine AIDS and expression of immunoglobulin E following infection with LP-BM5 murine leukemia viruses
35. Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice
36. Functional T lymphocytes are required for a murine retrovirus-induced immunodeficiency disease (MAIDS)
37. Possible role of interleukin-10 (IL-10) and CD40 ligand expression in the pathogenesis of hypergammaglobulinemia in human immunodeficiency virus infection: Modulation of IL-10 and Ig production after intravenous Ig infusion
38. A novel ligand on activated T helper cells binds CD40 and transduces the signal for the cognate activation of B cells
39. Immunopathology of B cell lymphomas induced in C57BL/6 mice by dualtropic murine leukemia virus (MuLV)
40. The nude mouse: A model of deficient T-cell function
41. Productive infection of normal CD40-activated human B lymphocytes by HIV-1
42. Developmental pathways of dendritic cells in vivo
43. Activated T cells induce expression of B7/BB 1 on normal or leukemic B cells through a CD40-dependent signal
44. Humoral immune responses in CD40 ligand-deficient mice
45. Plaque assay techniques for murine leukemia viruses
46. Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus
47. The many roles of CD40 in cell-mediated inflammatory responses
48. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion
49. Contribution of B cell subsets to delayed development of MAIDS in xid mice
50. Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threoninespecific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny
51. CD40 ligand-transduced co-stimulation of T cells in the development of helper function
52. + T cells are required for development of a murine retrovirus-induced immunodeficiency syndrome (MAIDS)
53. CD40-deficient mice infected with the defective murine leukemia virus LP-BM5def do not develop murine AIDS but produce IgE and IgG1 in vivo