Thrombin-mediated permeability of human microvascular pulmonary endothelial cells is calcium dependent

Journal of Trauma - Injury, Infection and Critical Care

Volumn 50, Issue 2, 2001, Pages 213-222

  Murphy, Joseph T ^a   Duffy, Steve L ^a   Hybki, Dixie L ^a   Kamm, Kristine ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTIN; BOVINE SERUM ALBUMIN; CALCIUM; F ACTIN; PHALLOIDIN; RHODAMINE; THROMBIN;

ACTIN FILAMENT; CALCIUM CELL LEVEL; CAPILLARY LEAK SYNDROME; CELL MEMBRANE PERMEABILITY; CELL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; MICROVASCULATURE; PRIORITY JOURNAL;

EID: 0035085781     PISSN: 00225282     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005373-200102000-00005     Document Type: Conference Paper

References (40)

1. Endothelial cell gene expression in response to injury
2. Prostacyclin synthesis induced in vascular cells by interleukin-1
3. Prolonged exposure of rat aorta to low levels of endotoxin in vitro results in impaired contractility. Association with vascular cytokine release
4. Myosin light chain kinase-regulated endothelial cell contraction: The relationship between isometric tension, actin polymerization, and myosin phosphorylation
5. Studies on inflammation I. The effect of histamine and serotonin on vascular permeability: Electron microscopic study
6. Regulation of smooth muscle contractile elements by second messengers
7. Calcium dependence of myosin light chain phosphorylation in smooth muscle cells
8. Regulation of endothelial cell myosin light chain phosphorylation. Role in thrombin-induced barrier dysfunction
9. Mechanisms of ionomycin-induced endothelial cell barrier dysfunction
10. Thrombin inactivates myosin light chain phosphatase via Rho and its target Rho kinase in human endothelial cells
11. The p160 Rho-A binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton
12. Influence of vasoactive agents on cytoplasmic free calcium in vascular endothelial cells
13. Reversible oxidant-induced increases in albumin transfer across cultured endothelium: Alterations in cell shape change and calcium homeostasis
14. Calcium dependence of the thrombin-induced increase in endothelial permeability
15. 2 biosynthesis. Role of guanine nucleotide-regulatory proteins
16. Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin
17. Relationship of burn size to vascular permeability changes in rats
18. Burn edema and protein leakage in the rat-I, relationship to time of injury
19. Stress fiber sarcomeres of fibroblasts are contractile
20. Different phosphorylated forms of myosin in contracting tracheal smooth muscle
21. Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat leukemia cells
22. The effect of histamine and cyclic adenosine monophosphate on myosin light chain phosphorylation in human umbilical vein endothelial cells
23. Actin-facilitated assembly of smooth muscle myosin induces formation of actomyosin fibrils
24. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
25. Signal transduction. Rhomantic interludes raise blood pressure
26. Correlation between thrombin-induced prostacyclin production and inositol triphosphate and cytosolic free calcium levels in cultured human endothelial cells
27. Pulmonary microvascular and macrovascular endothelial cells: Differential regulation of Ca2+ and permeability
28. Thrombin and histamine activate phospholipase C in human endothelial cells via a phorbol ester-sensitive pathway
29. Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin
30. Thrombin-induced increases in albumin clearance across cultured endothelial monolayers
31. Nature of thrombin-induced sustained increase in cytosolic calcium concentration in cultured endothelial cells
32. Human thrombin induces phosphoinositide turnover and Ca2+ movements in cultured human umbilical vein endothelial cells
33. Thrombin stimulates inositol phosphate accumulation and prostacyclin synthesis in human endothelial cells from umbilical vein but not from omentum
34. Protein kinase C activation alters the sensitivity of agonist-stimulated endothelial-cell prostacyclin production to intracellular Ca2+
35. Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase
36. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
37. Receptors on pulmonary endothelial cells
38. A leukocyte elastase inhibitor reduces thrombin-induced pulmonary oedema in the rat: Mechanisms of action
39. Thrombin-induced alterations in lung fluid balance in awake sheep
40. Inflammatory events following fibrin microembolization: Alteration in alveolar macrophage and neutrophil function