Venlafaxine occupation at the noradrenaline reuptake site: In-vivo determination in healthy volunteers

Journal of Psychopharmacology

Volumn 15, Issue 1, 2001, Pages 9-12

  Melichar, Jan K ^a   Haida, Abel ^b   Rhodes, Chris ^b   Reynolds, Alan H ^c   Nutt, David J ^a   Malizia, Andrea L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

Depression; Metahydroxyephedrine; Noradrenaline reuptake site; PET; Sympathetic; Venlafaxine

Indexed keywords

3 HYDROXYEPHEDRINE; ANTIDEPRESSANT AGENT; DESVENLAFAXINE; NORADRENALIN; NORADRENALIN UPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; VENLAFAXINE;

ARTICLE; CATECHOLAMINE UPTAKE; DRUG BLOOD LEVEL; FEMALE; HEART INNERVATION; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SYMPATHETIC NERVE CELL; WHOLE BODY COUNTING;

ADRENERGIC UPTAKE INHIBITORS; ADULT; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; AREA UNDER CURVE; CONTRAST MEDIA; CYCLOHEXANOLS; EPHEDRINE; FEMALE; HUMANS; MALE; NEURONS; NOREPINEPHRINE; RECEPTORS, ADRENERGIC; SYMPATHETIC NERVOUS SYSTEM; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0035085227     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988110101500102     Document Type: Article

References (18)

1. Comparison of the effects of venlafaxine, desipramine, and paroxetine on noradrenaline- and methoxamine-evoked constriction of the dorsal hand vein
2. Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: A comparative study with paroxetine and desipramine
3. Venlafaxine: Discrepancy between in viva 5-HT and NE reuptake blockade and affinity for reuptake sites
4. Comparison of the effects of venlafaxine, paroxetine and desipramine on the pupillary light reflex in man
5. The practical management of treatment resistant affective disorders
6. Simultaneous measurement of venlafaxine and its major metabolites oxydesmethylvenlafaxine in human plasma by high-performance liquid chromatography with coulometric detection and utilisation of solid phase extraction
7. Myocardial kinetics of carbon-11-meta-hydroxyephedrine: Retention mechanisms and effects of norepinephrine
8. 11C]-m-hydroxyephedrine in the rat
9. A new human (psycho)pharmacology tool: The multiple organs coincidences counter
10. Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo
11. Desipramine binding to noradrenaline reuptake sites in cardiac sympathetic neurons in man in vivo
12. Effects of active chronic cocaine use on cardiac sympathetic neuronal function assessed by carbon-11-hydroxyephedrine
13. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites
14. Venlafaxine and paroxetine in treatment-resistant depression. Double-blind, randomised comparison
15. Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity
16. Synthesis and preliminary evaluation of carbon-11-meta-hydroxyephedrine: A false transmitter agent for heart neuronal imaging
17. A randomized, double-blind, parallel-group comparison of venlafaxine and clomipramine in outpatients with major depression
18. Noninvasive evaluation of sympathetic nervous system in human heart by positron emission tomography