A randomized, double-blind, parallel-group comparison of venlafaxine and clomipramine in outpatients with major depression

Journal of Psychopharmacology

Volumn 12, Issue 3, 1998, Pages 273-278

  Samuelian, J C ^a   Hackett, David ^b,c  

^a TIMONE HOSPITAL   (France)

^b Wyeth Clin Research and Development   (France)

^c Wyeth Lederle CRD   (France)

Author keywords

Acute treatment; Clinical trial; Clomipramine; Major depression; Outpatients; Venlafaxine

Indexed keywords

ANTIDEPRESSANT AGENT; CLOMIPRAMINE; VENLAFAXINE;

ADULT; ANTICHOLINERGIC EFFECT; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ELECTROCARDIOGRAPHY; FEMALE; HAMILTON SCALE; HEADACHE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; OUTPATIENT; PRIORITY JOURNAL; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SOMNOLENCE; SYSTOLIC BLOOD PRESSURE; TACHYCARDIA; TREMOR; VERTIGO; XEROSTOMIA;

EID: 0031766010     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119801200307     Document Type: Article

References (35)

1. Benkert O, Gründer G, Wetzel H, Hackett D (1996) A randomized, double-blind comparison of a rapidly escalating dose of venlafaxine and imipramine in inpatients with major depression and melancholia. J Psychiat Res 30: 441-451
2. Bolden-Watson C, Richelson E (1993) Blockade by newly developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sci 52: 1023-1029
3. Clerc G E, Ruimy P, Verdeau-Pailes J (1994) A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia. Int Clin Psychopharmac 9: 138-143
4. Cunningham L A, Borison R L, Carman J S, Chouinard G, Crowder J E, Diamond B I, Fischer D E, Hearst E (1994) A comparison of venlafaxine, trazodone, and placebo in major depression. J Clin Psychopharmac 14: 99-106
5. Cusack B, Nelson A, Richelson E (1994) Binding of antidepressants to human brain receptors: focus on new generation compounds. Psychopharmacology 114: 559-565
6. Danish University Antidepressant Group (1986) Citalopram: clinical effect profile in comparison with clomipramine; a controlled multicenter study. Psychopharmacology 90: 131-138
7. Danish University Antidepressant Group (1990) Paroxetine: a selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Disord 18: 289-299
8. Danish University Antidepressant Group (1993) Moclobemide: a reversible MAO-A inhibitor showing weaker antidepressant effect than clomipramine in a controlled multicenter study. J Affect Disord 28: 105-116
9. Danjou P, Hackett D (1995) Safety and tolerance profile of venlafaxine. Int Clin Psychopharmac 10(Suppl. 2): 15-20
10. Derivan A, Entsuah A R, Kikta D (1995) Venlafaxine: measuring the onset of antidepressant action. Psychopharmac Bull 31: 437-445
11. Dierick M, Ravizza L, Realini R, Martin A (1996) A double-blind comparison of venlafaxine and fluoxetine for treatment of major depression in outpatients. Prog Neuropsychopharmac Biol Psychiat 20: 57-71
12. Entsuah A R, Rudolph R L, Chitra R (1995a) Effectiveness of venlafaxine treatment in a broad spectrum of depressed patients: a meta-analysis. Psychopharmac Bull 31: 759-766
13. Entsuah R, Upton G V, Rudolph R (1995b) Efficacy of venlafaxine treatment in depressed patients with psychomotor retardation or agitation: a meta-analysis. Hum Psychopharmac 10: 250-258
14. Eschalier A, Courty E, Rance J R (1990) Characteristics of orthostatic hypotension induced by clomipramine in depressed patients. Therapie 45: 75
15. Ferguson J, Khan A, Kucharik R, Leventer S, Cucci C (1994) A placebo-controlled comparative study of the effects of blood pressure and antidepressant efficacy of venlafaxine and imipramine (abstract). Neuropsychopharmacology 10: 165
16. Guelfi J D, White C, Hackett D, Guichoux J Y, Magni G (1995) Effectiveness of venlafaxine in patients hospitalized for major depression and melancholia. J Clin Psychiat 59: 450-458
17. Guy W (1976) ECDEU assessment manual for psychopharmacology, revised, DHEW Pub. No. (ADM) 76-338, National Institute of Mental Health, Rockville, MD
18. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiat 23: 56-62
19. Lecrubier Y, Moon C A L, Schifano F, Blanchard C, Danjou P, Hackett D (1997) Double-blind, randomized, placebo-controlled comparison of venlafaxine and imipramine in general practice patients with mild to moderate depression. Acta Psychiat Scand 95: 485-493
20. McTavish D, Benfield P (1990) Clomipramine: an overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39: 136-153
21. Mendels J, Johnston R, Mattes J, Riesenberg R (1993) Efficacy and safety of b.i.d. doses of venlafaxine in a dose-response study. Psychopharmac Bull 29: 169-174
22. Montgomery S A, Asberg M (1979) A new depression rating scale designed to be sensitive to change. Br J Psychiat 134: 382-389
23. Muth E A, Haskins J T, Moyer J A, Husbands G E M, Nielsen S T, Sigg E B (1986) Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative. Biochem Pharmac 35: 4493-4497
24. Muth E A, Moyer J A, Haskins J T, Andree T H, Husbands G E M (1991) Biochemical, neurophysiological, and behavioral effects of Wy-45, 233 and other identified metabolites of the antidepressant venlafaxine. Drug Dev Res 23: 191-199
25. Nierenberg A, Feighner J P, Rudolph R, Cole J O, Sullivan J (1994) Venlafaxine for treatment-resistant unipolar depression. J Clin Psychopharmac 14: 419-423
26. Pollock B G, Perel J M, Kupfer D J, Bowler K A, Miewald J M (1993) Early response patterns associated with successful clomipramine treatment. J Clin Psychopharmac 13: 442-447
27. Preskorn S H (1994) Antidepressant drug selection: criteria and options. J Clin Psychiat 55(Suppl. A): 6-22
28. Richelson E (1991) Biological basis of depression and therapeutic relevance. J Clin Psychiat 52(Suppl): 4-10
29. Richelson E (1994) Pharmacology of antidepressants - characteristics of the ideal drug. Mayo Clin Proc 69: 1069-1081
30. Rudolph R, Entsuah R, Derivan A (1991) Early clinical response in depression to venlafaxine hydrochloride. Biol Psychiat 29: 630S
31. Schweizer E, Feighner J, Mandos L, Rickels K (1994) Comparison of venlafaxine and imipramine in the acute treatment of major depression in outpatients. J Clin Psychiat 55: 104-108
32. Shrivastava R, Cohn C, Crowder J, Davidson J, Dunner D, Feighner J, Kiev A, Patrick R (1994) Long-term safety and clinical acceptability of venlafaxine and imipramine in patients with major depression. J Clin Psychopharmac 14: 99-106
33. Thase M E (1996) Antidepressant options: venlafaxine in perspective. J Clin Psychopharmac 16(Suppl. 2): 10S-20S
34. Trimble M R (1990) Worldwide use of clomipramine. J Clin Psychiat 51(Suppl): 51-54
35. Zimmer B, Kant R, Zeiller D, Brilmyer M (1996) Venlafaxine and blood pressure changes - spanning the ages. Annual Meeting of the American Psychiatric Association, May 7, New York, NY, p. 175. American Psychiatric Association, Washington, DC