Effect of the blood substitute diaspirin crosslinked hemoglobin in rat mesenteric and human radial collateral arteries

Journal of Cardiovascular Pharmacology

Volumn 37, Issue 4, 2001, Pages 394-405

  Vuylsteke, A ^a   Davidson, H J ^a   Ho, W S V ^a   Ritchie, A J ^a   Callingham, B A ^a   White, R ^a   Hiley, C R ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Diaspirin crosslinked hemoglobin; EDHF; Endothelial factors; Human collateral radial artery; Nitric oxide; Rat mesenteric artery

Indexed keywords

CARBACHOL; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DIASPIRIN CROSSLINKED HEMOGLOBIN; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INDOMETACIN; METHOXAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM CHLORIDE; PRAZOSIN;

ADULT; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; HUMAN; HUMAN TISSUE; MALE; MESENTERIC ARTERY; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RADIAL ARTERY; RAT; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ARTERIES; ASPIRIN; BLOOD SUBSTITUTES; BUCLADESINE; CARBACHOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HEMOGLOBINS; HUMANS; MALE; MESENTERIC ARTERIES; METHOXAMINE; MIDDLE AGED; MUSCLE CONTRACTION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; PEPTIDES, CYCLIC; PRAZOSIN; RATS; RATS, WISTAR; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 0035083780     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200104000-00006     Document Type: Article

References (30)

1. 2)
2. The renal handling of hemoglobin, I: Glomerular filtration
3. Cross-linked hemoglobin solution as a resuscitative fluid after hemorrhage in the rat
4. Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution
5. Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb™) as a vasopressor in critically ill patients
6. Characterization of diaspirin cross-linked hemoglobin's pressor response
7. Role of adrenergic mechanisms in the pressor effect of diaspirin cross-linked hemoglobin
8. T)) on isolated porcine blood vessels
9. Norepinephrine release during vasoconstriction induced by cross-linked hemoglobin
10. Actions of diaspirin cross-linked hemoglobin on isolated rat and dog vessels
11. Role of nitric oxide mechanism in cardiovascular effects of diaspirin cross-linked hemoglobin in anesthetized rats
12. The effects of cross-linked hemoglobin on regional vascular conductance in dogs
13. Effect of stroma-free hemoglobin and diaspirin cross-linked hemoglobin on the regional circulation and systemic hemodynamics
14. A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin
15. Role of ET and nitric oxide in resuscitative effect of diaspirin cross-linked hemoglobin after hemorrhage in rat
16. A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery
17. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats
18. Contribution of both nitric oxide and a change in membrane potential to acetylcholine-induced relaxation in the rat small mesenteric artery
19. + channel openers on relaxations to nitric oxide and endothelium-derived hyper-polarizing factor in rat mesenteric artery
20. Effects of pH on responses to adenosine, CGS 21680, carbachol and nitroprusside in the isolated perfused mesenteric arterial bed of the rat
21. Vascular activities of endothelin-1 and some alanyl substituted analogues in resistance beds of the rat
22. Preparation and characterization of diaspirin cross-linked hemoglobin solutions for preclinical studies
23. The action of diaspirin cross-linked haemoglobin on the reactivity of human isolated left internal mammary and radial arterial rings
24. Effect of diaspirin crosslinked and stroma-reduced hemoglobin on mean arterial pressure and endothelin-1 concentration in rats
25. Nonpeptide endothelin receptor antagonists attenuate the pressor effect of diaspirin-crosslinked hemoglobin in rat
26. Effect of diaspirin cross-linked hemoglobin on endothelin-1 and blood pressure in acute ischemic stroke in man
27. Cross-linked hemoglobin inhibits endothelium-dependent relaxations in isolated canine arteries
28. Action of a NO donor on the excitation-contraction pathway activated by noradrenaline in rat superior mesenteric artery
29. Endothelial regulation of vascular contraction in radial and internal mammary arteries
30. EDHF and residual NO: Different factors