Prognostic significance of p53, bcl-2, and bax protein expression in laryngeal squamous cell carcinoma: A multivariate analysis;Prognostische bedeutung der expression von p53, bcl-2 und bax im plattenepithel-karzinom des larynx - Eine multivariate analyse

HNO

Volumn 49, Issue 3, 2001, Pages 204-211

  Jackel M C ^a   Sellmann, L ^b   Youssef, S ^b   Dorudian, M A ^a   Fuzesi L ^b  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Bax; Bcl 2; Laryngeal carcinoma; P53; Prognostic factors

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ARTICLE; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; IMMUNOHISTOCHEMISTRY; LARYNX CARCINOMA; LYMPH NODE METASTASIS; MULTIVARIATE ANALYSIS; PROGNOSIS;

AGED; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LARYNGEAL NEOPLASMS; LARYNX; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0035079899     PISSN: 00176192     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001060050734     Document Type: Article

References (35)

1. p53-Mutationen/p53-Überexpressionen - Differentielle bedeutung für die progression von kopf-hals-karzinomen
2. Overexpression of p53 predicts organ preservation using induction chemotherapy and radiation in patients with advanced laryngeal cancer
3. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
4. Biological markers as indicators of pathological response to primary chemotherapy in oralcavity cancers
5. TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer
6. Prognostic significance of bcl-2 expression in localized squamous cell carcinoma of the head and neck
7. Bcl-2 protein expression correlates with recurrence and survival in earlx stage head and neck cancer treated by radiotherapy
8. Predictive and prognostic markers in a series of patients with head and neck squamous cell invasive carcinoma treated with concurrent chemoradiation therapy
9. Expression von zellzykluskomponenten in fortgeschrittenen kopf-hals-karzinomen
10. Down-regulation of bcl-2 by p53 in breast cancer cells
11. p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma
12. Enhanced apoptosis correlates with poor survival in patients with laryngeal cancer but not with cell proliferation, bcl-2 or p53 expression
13. Prognostic significance of clinical parameters and biological markers in patients with squamous cell carcinoma of the head and neck treated with concurrent chemoradiotherapy
14. Decreased expression of bax is correlated with poor prognosis in oral and oropharyngeal carcinoma
15. Die genetische kontrolle des programmierten zelltods (Apoptose)
16. The prognostic significance of the biomarkers p21 WAF1/CIP1, p53,and bcl-2 in laryngeal squamous cell carcinoma
17. Differential expression of bcl-2 and bax in squamous cell carcinomas of the oral cavity
18. Prognostic significance of clinical factors and p53 expression in patients with glottic carcinoma treated with radiation therapy
19. Apoptosis, cell proliferation and expression of bcl-2 and bax in gastric carcinomas: Immunohistochemical and clinicopathological study
20. Immunohistochemical determination of in vivo distribution of bax, a dominant inhibitor of bcl-2
21. Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma
22. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
23. p53 expression in normal, dysplastic, and neoplastic laryngeal epithelium. Absence of a correlation with prognostic factors
24. Is p53 an independent prognostic factor in patients with laryngeal carcinoma?
25. Overexpression of p53 protein does not predict local-regional control or survival in patients with early-stage squamous cell carcinoma of the glottic larynx treated with radiotherapy
26. L and bcl-2 expression in squamous cell carcinoma of the head and neck
27. Prognostic factors in laryngeal carcinoma
28. Clinical relevance of p53 and bcl-2 protein over-expression in laryngeal squamous-cell carcinoma
29. p53 overexpression in head and neck squamous cell carcinoma: A review of the literature
30. Expression level of bcl-2 determines anti- or proapoptotic function
31. Correlation of tumor markers p53, bcl-2, CD34, CD44H, CD44v6, and Ki-67 with survival and metastasis in laryngeal squamous cell carcinoma
32. p53 over-expression in laryngeal carcinoma is not predictive of response to radiotherapy
33. Tumorbiologische prognoseparameter beim T1NOMO-plattenepithelkarzinom der mundhöhle
34. Bcl-2 expression correlates with favourable outcome in head and neck cancer treated by accelerated radiotherapy
35. Bax expression has prognostic significance that is enhanced when combined with AgNOR counts in glottic carcinomas