Homozygous patients with the 20210 G to A prothrombin polymorphism remain often asymptomatic in spite of the presence of associated risk factors

Clinical and Applied Thrombosis/Hemostasis

Volumn 7, Issue 2, 2001, Pages 122-125

  Girolami, A ^a   Scarano, L ^a   Tormene, D ^a   Cella, G ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

Author keywords

Congenital thrombophilia; Hypercoagulability; Polymorphisms; Prothrombin; Thrombosis

Indexed keywords

PROTHROMBIN;

ADULT; AGED; ARTICLE; FEMALE; GENETIC POLYMORPHISM; HOMOZYGOSITY; HUMAN; HYPERCOAGULABILITY; MALE; PRIORITY JOURNAL; RISK FACTOR; SYMPTOMATOLOGY; THROMBOPHILIA; VEIN THROMBOSIS;

EID: 0035078211     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602960100700208     Document Type: Article

References (27)

1. A common genetic variation in the 3′ untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
2. The prothrombin 20210 G to A variation and thrombosis
3. The prothrombin gene variant 20210A in venous and arterial thromboembolism
4. Homozygous G20210A prothrombin gene mutation without thromboembolic events: A case report
5. Asymptomatic homozygous nt 20210 G to A prothrombin polymorphism in two blood donors belonging to two different kindreds
6. Two additional homozygous patients for the 20210 prothrombin polymorphism with no venous thrombosis
7. It is not sure yet whether the nt 20210 G to A prothrombin polymorphism represents a cause of familial venous thrombophilia or not
8. A further case of homozygous G 20210 A prothrombin gene mutation without thromboembolic events
9. A three generation family presenting five cases of homozygosity for the 20210 G to A prothrombin variant
10. Thrombosis in a patient with combined homozygosity for the factor V Leiden mutation and a mutation in the 3′-untranslated region of the prothrombin gene
11. Low incidence of venous thrombosis in homozygous patients with nt20210 G to A prothrombin polymorphism
12. A patient homozygous for a mutation in the prothrombin gene 3′-untranslated region associated with massive thrombosis
13. A prothrombin gene mutation is significantly associated with venous thrombosis
14. Homozygosity for a factor II polymorphism associated with thrombosis during pregnancy
15. A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin
16. Clinical and analytical relevance of the combination of prothrombin 20210A/A and factor V Leiden: Results from a large family
17. Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210 A/A prothrombin mutation and heterozygous 1691 G/A factor V Leiden mutation
18. Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene
19. Emphasis on congenital conditions predisposing to thrombosis should not make us disregard the importance of acquired factors
20. Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A prothrombin variant
21. Prothrombin and the prothrombin 20210 G to A polymorphism: Their relationship with hypercoagulability and thrombosis
22. Venous and arterial thrombophilia
23. Associations of disease with genetic markers: Dejà vu all ever again
24. Associations are not effects
25. Low rate of venous thromboembolism in asymptomatic relatives of probands with factor V Leiden mutation
26. Homozygous G20210A transition in the prothrombin gene associated with severe venous thrombotic disease: Two cases in a French family