A prothrombin gene mutation is significantly associated with venous thrombosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 17, Issue 11, 1997, Pages 2875-2879

  Kapur, Rajesh K ^a   Mills, Lisa A ^a   Spitzer, Silvia G ^a   Hultin, Mae B ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

Arterial thrombosis; Genetic mutation; Polymerase chain reaction; Prothrombin; Venous thrombosis

Indexed keywords

PROTHROMBIN;

ANTICOAGULATION; ARTICLE; CASE CONTROL STUDY; CHROMOSOME 11; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; HUMAN; HYPOTHESIS; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; STATISTICAL ANALYSIS; VEIN THROMBOSIS;

EID: 0031444184     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.17.11.2875     Document Type: Article

References (13)

1. De Stefano V, Finazzi G, Mannucci P. Inherited thrombophilia: pathogenesis, clinical syndromes, and management. Blood. 1996;87:3531-3544.
2. Dahlback B, Carlsson M, Svensson PJ. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A. 1993;90:1004-1008.
3. Bertina RM, Koeleman BPC, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994;369:64-68.
4. Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981;68:1370-1373.
5. Comp PC, Nixon RR, Cooper MR, Esmon CT. Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest. 1984;74:2082-2088.
6. Egeberg O. Inherited antithrombin deficiency causing thrombophilia. Thromb Diathes Haemorrh. 1965;13:516-530.
7. Haverkate F, Samama M. Familial dysfibrinogenemia and thrombophilia. Thromb Haemost. 1995;73:151-161.
8. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996;88:3698-3703.
9. Degen SJ, Davie EW. Nucleotide sequence of the gene for human prothrombin. Biochemistry. 1987;26:6165-6177.
10. Bums P, Hoffman CJ, Katz JP, Miller RH, Lawson WE, Hultin MB. Vitamin K-dependent clotting factors are elevated in young adults who have close relatives with ischemic heart disease. J Lab Clin Med. 1993;122:720-727.
11. Schefler WC. Statistics for Health Professionals. Reading, Mass: Addison-Wesley Publishing Co; 1984:230-238.
12. Forthofer RN, Lee ES. Introduction to Biostatistics: A Guide to Design, Analysis, and Discovery. San Diego, Calif: Academic Press Inc; 1995:298-303.
13. Schefler WC. Statistics for Health Professionals. Reading, Mass: Addison-Wesley Publishing Co; 1984:166-169.