The in vivo dermal absorption and metabolism of [4-14C]coumarin by rats and by human volunteers under simulated conditions of use in fragrances

Food and Chemical Toxicology

Volumn 39, Issue 2, 2001, Pages 153-162

  Ford, R A ^a   Hawkins, D R ^b   Mayo, B C ^b   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

^b HUNTINGDON LIFE SCIENCES   (United Kingdom)

Author keywords

Coumarin; Human; Rat; Skin absorption

Indexed keywords

ACETIC ACID DERIVATIVE; ALCOHOL; CARBON 14; COUMARIN; PERFUME; UMBELLIFERONE DERIVATIVE;

ADULT; ARTICLE; CONCENTRATION RESPONSE; FECES; FECES ANALYSIS; HUMAN; HUMAN EXPERIMENT; MALE; METABOLISM; METABOLITE; NONHUMAN; NORMAL HUMAN; PLASMA HALF LIFE; RADIOACTIVITY; RAT; SKIN ABSORPTION; TISSUE DISTRIBUTION; URINALYSIS; URINARY EXCRETION;

ADMINISTRATION, TOPICAL; ADULT; ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; COUMARINS; HUMANS; MALE; MIDDLE AGED; PERFUME; RATS; SKIN ABSORPTION; SOLUTIONS;

EID: 0035076864     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(00)00123-X     Document Type: Article

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