Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements

Journal of Bone and Mineral Research

Volumn 16, Issue 4, 2001, Pages 625-638

  Verlinden, Lieve ^a   Verstuyf, Annemieke ^a   Quack, Marcus ^b   Van Camp, Mark ^a   Van Etten, Evelyne ^a   De Clercq, Pierre ^c   Vandewalle, Maurits ^c   Carlberg, Carsten ^b   Bouillon, Roger ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

1,25 dihydroxyvitamin D3; 1,25 dihydroxyvitamin D3 receptor; 1,25 dihydroxyvitamin D3 responsive element; Analogs; Retinoid X receptor

Indexed keywords

14 EPIVITAMIN D3 DERIVATIVE; 19 NOR 14 EPI 23 YNE 1,25 DIHYDROXYVITAMIN D3; 19 NOR 14,20 1,25 DIHYDROXYVITAMIN D3; CALCITRIOL; COLECALCIFEROL DERIVATIVE; COLECALCIFEROL RECEPTOR; RETINOID X RECEPTOR; TX 522; TX 527; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; VITAMIN D RECEPTOR;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; PROTEIN CONFORMATION; PROTEIN STABILITY; VITAMIN D METABOLISM;

ADENOCARCINOMA; ALKYNES; ANIMALS; BREAST NEOPLASMS; CALCITRIOL; CELL DIVISION; CERCOPITHECUS AETHIOPS; CHOLECALCIFEROL; COS CELLS; DIMERIZATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; KETOCONAZOLE; MACROMOLECULAR SUBSTANCES; MICE; PROTEIN CONFORMATION; PROTEIN HYBRIDIZATION; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RETINOID X RECEPTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035076340     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.4.625     Document Type: Article

References (38)

1. The vitamin D endocrine system: Steroid metabolism, hormone receptors, and biological response (calcium binding proteins)
2. Remembrance: Discovery of the vitamin D endocrine system
3. 3 metabolites
4. 3
5. Vitamin D, calcium, and epidermal differentiation
6. 3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells
7. Structure-function relationships in the vitamin D endocrine system
8. 3 analogs: Effect on leukemic clonal growth and differentiation, and on serum calcium levels
9. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
10. Vitamin D receptor interaction with specific DNA. Association as a 1,25-dihydroxyvitamin D3-modulated heterodimer
11. 3 signalling
12. Two nuclear signaling pathways for vitamin D
13. 3 receptor in the context of the nuclear receptor superfamily: The central role of retinoid X receptor
14. Direct repeats as selective response element for the thyroid hormone, retinoic acid, and vitamin D3 receptors
15. Increasing the complexity of coactivation in nuclear receptor signaling
16. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
17. Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog
18. 3 receptor
19. 3 receptor-retinoid X receptor heterodimer-mediated transactivation
20. Selective recognition of vitamin D receptor conformations mediates promoter selectivity of vitamin D analogs
21. 24- And 26-homo-1,25-dihydroxyvitamin D3: Preferential activity in inducing differentiation of human leukemia cells HL-60 in vitro
22. Comparative study of the affinity of the serum vitamin D- binding protein
23. The biological activity of nonsteroidal vitamin D hormone analogs lacking both the C- and D-rings
24. 3 analog KH 1060
25. The high affinity ligand binding conformation of the nuclear 1,25-dihydroxyvitamin D3 receptor is functionally linked to the transactivation domain 2 (AF-2)
26. 3 receptor
27. 3 receptor binding site found in the rat atrial natriuretic factor promoter
28. 3 response element identified in the mouse c-fos promoter
29. The role of the T-box for the formation of the vitamin D receptor on different types of response elements
30. Distinct conformational changes induced by 20-epi-analogues of 1α,25-dihydroxyvitamin D3 are associated with enhanced activation of the vitamin D receptor
31. 3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1,25-dihydroxyvitamin D3
32. 3 analogues and their 20-epi homologues with the vitamin D receptor
33. Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction
34. The nuclear receptor ligand-binding domain: Structure and function
35. 3 and its A-ring modified analogs
36. Studies on the interaction between the vitamin D receptor and the radio-labelled 20-epi vitamin D analogue GS 1500
37. 3 analogs
38. DNA bending is induced by binding of vitamin D receptor-retinoid X receptor heterodimers to vitamin D response elements