Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene

British Journal of Pharmacology

Volumn 132, Issue 7, 2001, Pages 1485-1492

  Maldonado, Rafael ^a   Severini, Cintia ^b   Matthes, Hans W D ^c   Kieffer, Brigitte L ^c   Melchiorri, Pietro ^d   Negri, Lucia ^d  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b CNR   (Italy)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Delta opioid receptor; Deltorphins; Dermorphins; Knock out mice; Morphine; Mu opioid receptor; Synthetic peptides; Vas deferens

Indexed keywords

DELTA OPIATE RECEPTOR AGONIST; DELTORPHIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MORPHINE; MU OPIATE RECEPTOR AGONIST; NALTRINDOLE;

AGONIST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG SELECTIVITY; MALE; MOUSE; MOUSE MUTANT; NEWBORN; NONHUMAN; PRIORITY JOURNAL; VAS DEFERENS;

EID: 0035075423     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703966     Document Type: Article

References (38)

1. Genotype dependent response of morphine and methionine-enkephalin on the electrically induced contractions of the mouse vas deferens
2. Selectivity of ligands of opioid receptors
3. The opioid peptides of the amphibian skin
4. Deltorphins: A family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites
5. Guinea-pig ileum and mouse vas deferens preparations in the discovery, discrimination and parallel bioassay of opioid peptides
6. Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors
7. 61-66 possessing selective agonist activity at mu-opiate receptors
8. Delta-opioid receptor agonists produce antinociception and (S-35)GTPγS binding in mu receptor knockout mice
9. Effects of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antagonist potencies of narcotic analgesics
10. Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides
11. Opioids: First lessons from knockout mice
12. Deltorphin, a novel amphibian skin peptide with high selectivity and affinity for delta opioid receptors
13. Gastrointestinal effects of opioids
14. Opioid binding properties of brain and peripheral tissues: Evidence for heterogeneity in opioid ligand binding sites
15. Mu opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality
16. Endogenous opioid peptides: Multiple agonists and receptors
17. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the μ-opioid-receptor gene
18. Activity of the delta-opioid receptor is partially reduced while activity of the kappa-receptor is maintained in mutant mice lacking the mu-receptor
19. The dermorphin peptide family
20. Structure-activity relationships of the delta-opioid-selective agonists, deltorphins
21. Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors
22. Absence of G-protein activation by mu-opioid receptor agonists in the spinal cord of mu-opioid receptor knockout mice
23. Glycodermorphins: Opioid peptides with potent and prolonged analgesic activity and enhanced blood-brain barrier penetration
24. Dermorphin-related peptides from the skin of Pyllomedusa bicolor and their amidated analogs activate two mu opioid receptors subtypes which modulate antinociception and catalepsy in the rat
25. Neutral endopeptidase 24.11: Structure, inhibition, and experimental and clinical pharmacology
26. Opioid receptor binding profile of selected dermorphin-like peptides
27. Allosteric coupling among opioid receptors: Evidence for an opioid receptor complex
28. Molecular determination of receptor affinity and selectivity of the natural delta-opioid agonist Dermenkephalin
29. Cross-linking of human [125I]beta-endorphin to opioid receptors in rat striatal membranes: Biochemical evidence for the existence of a mu/delta opioid receptor complex
30. Use of organ systems for opioid bioassay
31. The mu-opioid receptor is necessary for [D-Pen2,D-Pen5]enkephalin-induced analgesia
32. Mu opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia
33. Visceral chemical nociception in mice lacking mu-opioid receptors: Effects of morphine, SCN80 and U-50,488
34. Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors
35. Delta-opioid receptor subtypes and cross-talk with mu-receptors
36. Mu and delta receptors: Their role in analgesia in the differential effects of opioid peptides on analgesia
37. Differentiation between rat brain and mouse vas deferens delta opioid receptor